Evidence map›Paper›PMID 34414564›Full record

ReviewDrug delivery and translational research2021

Biomaterial-based immunotherapeutic strategies for rheumatoid arthritis.

Allen B Tu, Jamal S Lewis

Open access · bronzeAbstract readReview
In one paragraph

Review in Drug delivery and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Live macrophages loaded with FeMaterials today. Bio · 2024
    Article
  7. Nanocarriers for Cannabinoid Delivery: Enhancing Therapeutic Potential.Recent advances in drug delivery and formulation · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Overcoming transport barrier to immunotherapies.Drug delivery and translational research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Allen B TuDepartment of Biomedical Engineering, University of California, 1 Shields Ave, Davis , CA, 95616, USA.
Jamal S LewisDepartment of Biomedical Engineering, University of California, 1 Shields Ave, Davis , CA, 95616, USA. jamlewis@ucdavis.edu.ORCID http://orcid.org/0000-0002-9811-8538
University of California, Davis · USUniversity of California System · US

Funding

Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Particulate-based in vivo modulation for immunotherapy of Rheumatoid ArthritisR01AI139399 · NIAID · UNIVERSITY OF FLORIDA · PI LEWIS, JAMAL S · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI139399NIGMS NIH HHS T32 GM099608
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an extremely painful autoimmune disease characterized by chronic joint inflammation leading to the erosion of adjacent cartilage and bone. Rheumatoid arthritis pathology is primarily driven by inappropriate infiltration and activation of immune cells within the synovium of the joint. There is no cure for RA. As such, manifestation of symptoms entails lifelong management via various therapies that aim to generally dampen the immune system or impede the function of immune mediators. However, these treatment strategies lead to adverse effects such as toxicity, general immunosuppression, and increased risk of infection. In pursuit of safer and more efficacious therapies, many emerging biomaterial-based strategies are being developed to improve payload delivery, specific targeting, and dose efficacy, and to mitigate adverse reactions and toxicity. In this review, we highlight biomaterial-based approaches that are currently under investigation to circumvent the limitations of conventional RA treatments.

Indexed as

Arthritis, RheumatoidBiocompatible MaterialsHumansImmunotherapyBiocompatible MaterialsAutoimmunityBiomaterialsDrug deliveryNanomedicineRheumatoid arthritis

Identifiers

PMID34414564
PMCPMC8376117
OpenAlexW3194574225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.