SynthesisClinical oral investigations2021
Prenatal, perinatal and postnatal events associated with hypomineralized second primary molar: a systematic review with meta-analysis.
Synthesis in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Secondhand smoke exposure and human health: an umbrella review.Nature human behaviour · 2026Pooled it
- Global prevalence of hypomineralised second primary molars: an updated systematic review with a meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Are low serum levels of Vitamin D associated with dental developmental defects in primary teeth? A systematic review.Evidence-based dentistry · 2024Pooled it
- Prevalence and characteristics of hypomineralised second primary molars in Irish school children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Prevalence and Associated Factors of Hypomineralised Second Primary Molars in 3-5-Year-Old Children in Aydın, Türkiye.Oral health & preventive dentistry · 2026Article
- Presumptive Bilirubin-Related Chlorodontia and Developmental Enamel Defects of the Primary Dentition in an Extremely Preterm Infant: A Case Report.Journal of clinical medicine · 2026Article
- Prenatal and birth-related risk factors for hypomineralised second primary molars: a prospective cohort study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Children with unilateral molar-incisor hypomineralisation (MIH) may exhibit contralateral temporalis and masseter muscle hyperactivity: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Observational
- Prevalence, clinical presentation and risk factors of molar incisor hypomineralisation and hypomineralised second primary molars among children in Buraydah, Saudi Arabia: A cross-sectional study.Journal of public health research · 2025Article
- MMP-9 expression in rat pup incisor teeth is not altered by maternal hypertension or maternal atenolol treatment during pregnancy and lactation.Journal of molecular histology · 2024Article
- Prevalence of hypomineralized second primary molars and association with socioeconomic characteristics and dental caries in a Brazilian population of preschoolers: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Hypomineralised second primary molars: the Würzburg concept.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Review
- Household smoking impact on the oral health of 5- to 7-years-old children.BMC oral health · 2023Article
- Is Aberrant DNA Methylation a Key Factor in Molar Incisor Hypomineralization?Current issues in molecular biology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe etiology of hypomineralized second primary molar (HSPM) appears to be multifactorial but remains uncertain. Thus, the objective was to systematically review studies that investigated adverse health conditions in the prenatal, perinatal and postnatal periods associated with HSPM. MATERIAL AND
methodsThe search was carried out in five databases and in gray literature. The risk of bias of observational studies was analyzed according to the Newcastle-Ottawa scale.
resultsA total of 1878 studies were identified. Fourteen were eligible, and seven were included in the meta-analysis. Maternal smoking (OR = 2.88; 95%CI: 1.62-5.15) and presence of maternal hypertension (OR = 2.91; 95%CI: 1.35-6.28) were significantly associated with higher odds of HSPM. In the perinatal period, factors associated with HSPM were low birth weight (OR = 1.50; 95%CI: 1.15-1.96), prematurity (OR = 1.93; 95%CI: 1.37-2.71), delivery complications (OR = 2.42; 95%CI: 1.52-3.83) and need for an incubator (OR = 1.65; 95%CI: 1.01-2.70). Not breastfeeding (OR = 1.26; 95%CI: 1.01-1.58), use of antibiotics by the child (OR = 1.24; 95%CI: 1.04-1.48), fever (OR = 1.37; 95%CI: 1.10-1.72) and asthma (OR = 1.91; 95%CI: 1.16-3.13) were the postnatal factors associated with HSPM.
conclusionMaternal smoking, maternal hypertension, low birth weight, prematurity, delivery complications, need for incubation, not breastfeeding, antibiotic use, fever and childhood asthma were associated with HSPM. Well-designed prospective cohort studies are needed. Clinical relevance Understanding the etiological factors can be guiding aspects for individual clinical approaches, as well as guiding the design of preventive interventions for HSPM.
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