ArticlePediatric nephrology (Berlin, Germany)2022
Survival of infants treated with CKRT: comparing adapted adult platforms with the Carpediem™.
Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Current practices in pediatric continuous kidney replacement therapy: a systematic review-guided multinational modified Delphi consensus study.Pediatric nephrology (Berlin, Germany) · 2023Pooled it
- Kidney Damage and Stress Biomarkers for Early Identification of Drug-Induced Kidney Injury: A Systematic Review.Drug safety · 2022Pooled it
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Dialysis modality and mortality of the Contemporary Infant and Neonatal Dialysis (COINED) Cohort: a Pediatric Nephrology Research Consortium (PNRC) study.Pediatric nephrology (Berlin, Germany) · 2026Article
- [Interpretation of the "Expert consensus on the diagnosis and treatment of neonatal hyperammonemia"].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- AEIOU strategy for continuous renal replacement therapy in infants <10 kg: a practical and educational framework.Frontiers in pediatrics · 2025Review
- Provision of continuous renal replacement therapy in children in intensive care in Australia and New Zealand.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Continuous renal replacement therapy in neonates and children: what does the pediatrician need to know? An overview from the Critical Care Nephrology Section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC).European journal of pediatrics · 2024Review
- New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Article
- A simplified protocol of regional citrate anticoagulation with phosphate-containing solutions in infants and children treated with continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2023Article
- Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK).Kidney international reports · 2023Article
- CARPEDIEM® for continuous kidney replacement therapy in neonates and small infants: a French multicenter retrospective study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Safety and efficacy of continuous renal replacement therapy for children less than 10 kg using standard adult machines.European journal of pediatrics · 2023Article
- Kidney support for babies: building a comprehensive and integrated neonatal kidney support therapy program.Pediatric nephrology (Berlin, Germany) · 2023Review
- Acute kidney injury and early fluid load in a retrospective cohort of neonatal sepsis.Pediatric nephrology (Berlin, Germany) · 2023Article
- Management of Acute Kidney Injury in Critically Ill Children.Indian journal of pediatrics · 2023Review
- Improving acute peritoneal dialysis outcome with use of soft peritoneal dialysis catheter (Cook Mac-Loc Multipurpose Drainage catheter®) among infants < 1500 g in a low resource setting.Pediatric nephrology (Berlin, Germany) · 2023Article
- Continuous Kidney Replacement Therapy Practices in Pediatric Intensive Care Units Across Europe.JAMA network open · 2022Article
- Standardizing Care in Pediatric Continuous Kidney Replacement Therapy-Can We Reach Consensus Without Adequate Evidence?JAMA network open · 2022Article
- Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury.Intensive care medicine · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most severely ill neonates and infants with AKI who need kidney replacement therapy have had to rely upon peritoneal dialysis, or adaptations of veno-venous continuous kidney replacement therapy (CKRT) devices for adults. Data from the Prospective Pediatric CRRT (ppCRRT) registry observed children < 10 kg had a lower survival rate than children > 10 kg (44% vs. 64%, p < 0.001). A CKRT device designed specifically for small children could improve outcomes. The Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM™) is specifically dedicated to providing CKRT for newborns and small infants.
methodsWe performed a retrospective cohort analysis comparing patient severity of illness and outcomes between the ppCRRT and CARPEDIEM registries, involving 6 Italian pediatric intensive care units. Thirty-eight subjects from the CARPEDIEM registry and 84 subjects from the ppCRRT registry < 10 kg were screened for comparison. We compared patient outcomes with a weight-matched cohort (< 5 kg) of 34 patients from the CARPEDIEM registry and 48 patients from the ppCRRT registry.
resultsThe ppCRRT subjects had higher rates of vasoactive medication at CKRT initiation. Survival to CKRT termination was higher for CARPEDIEM subjects (33/34 vs. 21/48, p < 0.0001). Multivariable logistic regression showed that CARPEDIEM registry cohort was the only variable to retain an association with survival to CKRT discontinuation.
conclusionsWe suggest children receiving CKRT using CARPEDIEM have excellent survival. Our data should be interpreted with caution given the retrospective comparison across two eras more than a decade apart.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.