Evidence map›Paper›PMID 34414449›Full record

ArticleMolecular medicine reports2021

Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR‑1276/SIRT4 axis.

Lingli Xu, Ke Xu, Lijun Xiang, Jiamei Yan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lingli XuDepartment of Ultrasound, Ningbo Zhenghai Longsai Hospital, Ningbo, Zhejiang 315200, P.R. China.
Ke XuDepartment of Radiology, Ningbo Zhenghai Traditional Chinese Medicine Hospital, Ningbo, Zhejiang 315200, P.R. China.
Lijun XiangDepartment of Ultrasound, Ningbo Zhenghai Longsai Hospital, Ningbo, Zhejiang 315200, P.R. China.
Jiamei YanDepartment of Ultrasound, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang 315040, P.R. China.
Ningbo Medical Center Lihuili Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mounting evidence has indicated that circular RNAs (circRNAs) serve essential roles in the tumorigenesis and development of various types of cancer. However, the biological functions and the underlying mechanisms of circRNAs in breast cancer (BC) remain largely elusive. In the present study, the expression pattern of circRNAs in three pairs of BC tissues and adjacent normal tissues was determined using a circRNA microarray. The expression and prognostic value of circOMA1 were evaluated by reverse transcription‑quantitative PCR in 64 pairs of BC tissues and adjacent normal tissues. Survival curves were generated by the Kaplan‑Meier method, and statistical significance was estimated using the log‑rank test. A series of

Indexed as

RNA, CircularAdultAgedApoptosisBiomarkers, TumorBreast NeoplasmsCarcinogenesisCell Line, TumorCell MovementCell SurvivalGene Expression Regulation, NeoplasticHEK293 CellsHumansMetalloendopeptidasesMicroRNAsMiddle AgedBiomarkers, TumorMetalloendopeptidasesMicroRNAsMIRN-1276 microRNA, humanMitochondrial Proteinsmolecule metalloprotease-related protein-1, humanRNA, CircularSIRT4 protein, humanSirtuinsbreast cancercircular RNA OMA1microRNA‑1276sirtuin 4

Identifiers

PMID34414449
PMCPMC8383036
OpenAlexW3195028228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.