ArticleInternational journal of epidemiology2022
Association and pathways between shift work and cardiovascular disease: a prospective cohort study of 238 661 participants from UK Biobank.
Article in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Association between night shift work and cardiovascular disease: a systematic review and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- Occupational Risk for Coronary Artery Disease in Shift Workers - A Systematic Review.La Medicina del lavoro · 2024Pooled it
- The Risk of Cardiovascular Diseases for Shift Workers in the Prospective Heinz Nixdorf Recall Study.American journal of industrial medicine · 2026Article
- Rotating Night Shift Work and Risk of Incident Cardiovascular Disease and Mortality by Chronotype: A Prospective Cohort Study in Nurses' Health Study II.medRxiv : the preprint server for health sciences · 2026Article
- Role of Life's Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants.Journal of global health · 2026Article
- Night shift work and the acceleration of chronic kidney disease onset: dose-response relationships, interactions with cardiometabolic genetic risk, and metabolomic mediators.Scandinavian journal of work, environment & health · 2026Article
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Cardiovascular Risk and Modifiable Risk Factors in Shift-Working Healthcare Workers: A Gender-Stratified Cross-Sectional Study.Journal of clinical medicine · 2026Article
- The association of night shift work with the risk of acute ischemic cerebrovascular syndrome: a longitudinal study of 204,261 UK Biobank participants.Journal of neurology · 2026Article
- Shift work and the risk of incident hospital-treated infections: quantifying the role of lifestyle factors.BMC infectious diseases · 2026Article
- Long-term prognosis of cardiometabolic diseases among U.S. workers: The contribution of shift work to mortality.American journal of preventive cardiology · 2026Article
- Associations between shift work patterns and sleep disturbance: an analysis of cross-sectional data from UK Biobank.BMJ open · 2026Article
- Increased risk of asthma in female night shift workers.ERJ open research · 2025Article
- Occupational Risk Factors for Cardiovascular Disease: A Comprehensive Review.Current cardiology reports · 2025Review
- The association between irregular working hours and cardiovascular diseases in a multi-ethnic population: the HELIUS study.Occupational medicine (Oxford, England) · 2025Observational
- Associations between shift work and biological age acceleration: A population-based study.GeroScience · 2025Article
- Association between health literacy and behaviors among shift workers: an observational cross-sectional study with mediation analysis.Journal of occupational health · 2025Observational
- The roles of lifestyle factors and genetic risk in the association between night shift work and cholelithiasis: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Circadian de(regulation) in physiology: implications for disease and treatment.Genes & development · 2024Review
- Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study aimed to study the association between shift work and incident and fatal cardiovascular disease (CVD), and to explore modifying and mediating factors.
methodsThis is a population-based, prospective cohort study with a median follow-up of 11 years; 238 661 UK Biobank participants who were in paid employment or self-employed at baseline assessment were included.
resultsShift workers had higher risk of incident [hazard ratio (HR) 1.11, 95% confidence interval (CI) 1.06-1.19] and fatal (HR 1.25, 95% CI 1.08-1.44) CVD compared with non-shift workers, after adjusting for socio-economic and work-related factors. The risk was higher with longer duration of shift work, in women and in jobs with little heavy manual labour. Current smoking, short sleep duration, poor sleep quality, adiposity, higher glycated haemoglobin and higher cystatin C were identified as the main potentially modifiable mediators. Mediators collectively explained 52.3% of the associations between shift work and incident CVDs.
conclusionsShift workers have higher risk of incident and fatal CVD, partly mediated through modifiable risk factors such as smoking, sleep duration and quality, adiposity and metabolic status. Workplace interventions targeting these mediators have the potential to alleviate shift workers' CVD risk.
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