ArticleJournal of affective disorders reports2021
Plasma homocysteine concentrations and depression: A twin study.
Article in Journal of affective disorders reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- The pattern of dissociative symptoms differs between post-traumatic stress disorder and first esketamine administration for treatment-resistant depression.Journal of affective disorders · 2025Article
- Serum folate and homocysteine as biomarkers for suicide risk in major depressive disorder: insights in males and younger patients.BMC psychiatry · 2025Observational
- Unraveling Gender Differences in Obsessive-Compulsive Disorder: A Focus on Key Micronutrients.Cureus · 2025Article
- Association Between Riboflavin Intake and Suicidal Ideation: A Nationwide Study in Korea.Nutrients · 2025Article
- Association between homocysteine levels and cognition in late-life depression.Frontiers in psychiatry · 2025Article
- Psychometric properties of the 23-Item Clinician Administered Dissociative States Scale (CADSS) in a psychological trauma population.Journal of affective disorders · 2024Article
- Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study.Translational psychiatry · 2024Article
- Biomarkers Associated with Depression Improvement in Veterans with Gulf War Illness Using the Low-Glutamate Diet.Nutrients · 2024Article
- Association between major dietary patterns and mental health problems among college students.Journal of education and health promotion · 2024Article
- Common Variants in One-Carbon Metabolism Genes (International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHomocysteine is an amino acid formed during metabolism of the essential amino acid methionine that plays an important role in energy metabolism and neurotransmitter synthesis. High levels of homocysteine have been linked to both depression and cardiovascular disease, however studies of depression have not always been consistent, possibly related to differences in methodology among studies. The study of twins in clinical research can be useful in controlling for confounding factors. The purpose of this study was to assess the relationship between depression and plasma homocysteine in a study of twins.
methodsHomocysteine concentration was assessed in twins (
resultsThe average homocysteine concentration was 7.9 μmol/L (2.1 μmol/L SD, range of 2.0-17.1 μmol/L). There were no within twin pair differences in homocysteine concentration within twin pairs discordant for MDD and within twin pairs that differed for BDI score. There was a significant pair-level relationship between depressive symptoms as measured by mean BDI score and homocysteine concentration, such that the higher the mean BDI score of the twin pair, the higher the mean homocystein of the pair (
conclusionsThese findings are not consistent with a causal role for elevated homocysteine in the development of depression, but rather point to familial confounding or other factors that are shared by twin brothers and that contribute to both depression and homocysteine levels.
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