Evidence map›Paper›PMID 34414381›Full record

ArticleJournal of magnetic resonance open2021

Preclinical MRI to Quantify Pulmonary Disease Severity and Trajectories in Poorly Characterized Mouse Models: A Pedagogical Example Using Data from Novel Transgenic Models of Lung Fibrosis.

Ian R Stecker, Matthew S Freeman, Sneha Sitaraman, Chase S Hall, Peter J Niedbalski, Alexandra J Hendricks, Emily P Martin, Timothy E Weaver, Zackary I Cleveland

Abstract read
In one paragraph

Article in Journal of magnetic resonance open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Choosing the right animal model for sarcoma research.Cellular and molecular life sciences : CMLS · 2026
    Review
  2. Article
  3. Impact of undersampling on preclinical lung TJournal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  4. Article
  5. Utilizing MRI, [Frontiers in nuclear medicine · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ian R SteckerDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221.
Matthew S FreemanCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Sneha SitaramanDivision of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Chase S HallDivision of Pulmonary and Critical Care, University of Kansas Medical Center, Kansas City, KS 66160.
Peter J NiedbalskiCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Alexandra J HendricksDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221.
Emily P MartinDivision of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Timothy E WeaverDepartment of Pediatrics, University of Cincinnati, Cincinnati, OH 45221.
Zackary I ClevelandDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221.

Funding

Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
The Role of Autophagy in the Pathogenesis of interstitial Lung DiseaseR01HL103923 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WEAVER, TIMOTHY EDWARD · 2011 to 2014
$2.0M
Time-Resolved 129Xe Ventilation-Perfusion MRI in Models of Acute Lung InjuryR00HL111217 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2015 to 2017
$728k
NHLBI NIH HHS R00 HL111217NHLBI NIH HHS R01 HL103923NHLBI NIH HHS R01 HL143011
6 · The paper itself

Abstract

Structural remodeling in lung disease is progressive and heterogeneous, making temporally and spatially explicit information necessary to understand disease initiation and progression. While mouse models are essential to elucidate mechanistic pathways underlying disease, the experimental tools commonly available to quantify lung disease burden are typically invasive (

Identifiers

PMID34414381
PMCPMC8372031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.