Evidence map›Paper›PMID 34414346›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2021

Developing the building blocks to elucidate the impact of the urban exposome on cardiometabolic-pulmonary disease: The EU EXPANSE project.

Jelle Vlaanderen, Kees de Hoogh, Gerard Hoek, Annette Peters, Nicole Probst-Hensch, Augustin Scalbert, Erik Melén, Cathryn Tonne, G Ardine de Wit, Marc Chadeau-Hyam and 4 more

Abstract read
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jelle VlaanderenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Kees de HooghInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Gerard HoekInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Annette PetersHelmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nicole Probst-HenschSwiss Tropical Health, Basel, Switzerland.
Augustin ScalbertInternational Agency for Research on Cancer (IARC), Biomarkers Group, Lyon, France.
Erik MelénDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Cathryn TonneBarcelona Institute for Global Health (ISGlobal), Universitat Pompeu Fabra, CIBER Epidemiología y Salud Pública, Barcelona, Spain.
G Ardine de WitDepartment of health care innovation and evaluation, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Marc Chadeau-HyamInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Klea KatsouyanniImperial College London, London, United Kingdom.
Tõnu EskoUniversity of Tartu, Tartu, Estonia.
Karin R JongsmaDepartment of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Roel VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

Funding

Medical Research Council MR/S019669/1World Health Organization 001
6 · The paper itself

Abstract

By 2030, more than 80% of Europe's population will live in an urban environment. The urban exposome, consisting of factors such as where we live and work, where and what we eat, our social network, and what chemical and physical hazards we are exposed to, provides important targets to improve population health. The EXPANSE (EXposome Powered tools for healthy living in urbAN SEttings) project will study the impact of the urban exposome on the major contributors to Europe's burden of disease: Cardio-Metabolic and Pulmonary Disease. EXPANSE will address one of the most pertinent questions for urban planners, policy makers, and European citizens: "How to maximize one's health in a modern urban environment?" EXPANSE will take the next step in exposome research by (1) bringing together exposome and health data of more than 55 million adult Europeans and OMICS information for more than 2 million Europeans; (2) perform personalized exposome assessment for 5,000 individuals in five urban regions; (3) applying ultra-high-resolution mass-spectrometry to screen for chemicals in 10,000 blood samples; (4) evaluating the evolution of the exposome and health through the life course; and (5) evaluating the impact of changes in the urban exposome on the burden of cardiometabolic and pulmonary disease. EXPANSE will translate its insights and innovations into research and dissemination tools that will be openly accessible via the EXPANSE toolbox. By applying innovative ethics-by-design throughout the project, the social and ethical acceptability of these tools will be safeguarded. EXPANSE is part of the European Human Exposome Network.

Indexed as

Cardiometabolic diseaseEthics parallel researchEuropean Human Exposome NetworkExposomeLife course epidemiologyOMICSPulmonary diseaseUltra-high-resolution massspectrometryUrban exposome

Identifiers

PMID34414346
PMCPMC8367039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.