Evidence map›Paper›PMID 34414307›Full record

ArticleEuropean stroke journal2021

European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA.

Jesse Dawson, Áine Merwick, Alastair Webb, Martin Dennis, Julia Ferrari, Ana Catarina Fonseca, European Stroke Organisation

RetractedAbstract readRetracted Publication
In one paragraph

Article in European stroke journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review and synthesis of global stroke guidelines on behalf of the World Stroke Organization.International journal of stroke : official journal of the International Stroke Society · 2023
    Pooled it
  2. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jesse DawsonCollege of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0001-7532-2475
Áine MerwickDepartment of Neurology, Cork University Hospital, Cork, Ireland.ORCID https://orcid.org/0000-0001-7533-0117
Alastair WebbWolfson Centre for Prevention of Stroke and Dementia, Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-0630-8204
Martin DennisCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Julia FerrariDepartment of Neurology, St. John's of God Hospital, Vienna Austria.
Ana Catarina FonsecaDepartment of Neurosciences (Neurology), Hospital de Santa Maria, University of Lisbon, Lisboa, Portugal.ORCID https://orcid.org/0000-0001-6913-5526
European Stroke Organisation

Funding

Wellcome Trust 206589/Z/17/Z
6 · The paper itself

Abstract

Prevention of early recurrent ischaemic stroke remains a priority in people with TIA or ischaemic stroke. A number of trials have recently been completed assessing the efficacy of short-term dual antiplatelet therapy (DAPT) versus single antiplatelet therapy early after minor or moderate stroke or high-risk TIA. We present an Expedited Recommendation for use of dual antiplatelet therapy early after ischaemic stroke and TIA on behalf of the ESO Guideline Board. We make a strong recommendation based on high quality of evidence for use of 21-days of dual antiplatelet therapy with aspirin and clopidogrel in people with a non-cardioembolic minor ischaemic stroke or high-risk TIA in the past 24 hours. We make a weak recommendation based on moderate quality evidence for 30-days of dual antiplatelet therapy with aspirin and ticagrelor in people with non-cardioembolic mild to moderate ischaemic stroke or high-risk TIA in the past 24 hours.

Indexed as

antiplateletsStrokeTIA

Identifiers

PMID34414307
PMCPMC8370061

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.