Evidence map›Paper›PMID 34414119›Full record

ArticleLiver cancer2021

Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals.

Tatsuya Minami, Ryosuke Tateishi, Naoto Fujiwara, Ryo Nakagomi, Takuma Nakatsuka, Masaya Sato, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Hidetaka Fujinaga and 32 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 1 country.

Tatsuya MinamiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ryosuke TateishiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Naoto FujiwaraDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ryo NakagomiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takuma NakatsukaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masaya SatoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Koji UchinoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kenichiro EnookuDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hayato NakagawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hidetaka FujinagaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Masashi IzumiyaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kazuyuki HanajiriDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshinari AsaokaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yuji KondoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yasuo TanakaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Motoyuki OtsukaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takamasa OhkiDepartment of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan.
Masahiro AraiDepartment of Gastroenterology, Toshiba General Hospital, Toshiba, Japan.
Atsushi TanakaDepartment of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Kiyomi YasudaDepartment of Gastroenterology, Kiyokawa Hospital, Tokyo, Japan.
Hideaki MiuraDepartment of Gastroenterology, Tokyo Yamate Medical Center, Tokyo, Japan.
Itsuro OgataDepartment of Gastroenterology, Kawakita General Hospital, Tokyo, Japan.
Toshiro KamoshidaDepartment of Gastroenterology, Hitachi General Hospital, Hitachi, Japan.
Kazuaki InoueDepartment of Gastroenterology, Showa University Fujigaoka Hospital, Yokohama, Japan.
Yukihiro KoikeDepartment of Gastroenterology, Kanto Central Hospital of the Mutual Aid Association of Public School Teacher, Tokyo, Japan.
Masatoshi AkamatsuDepartment of Gastroenterology, JR Tokyo General Hospital, Tokyo, Japan.
Hiroshi MitsuiDepartment of Gastroenterology, Tokyo Teishin Hospital, Tokyo, Japan.
Hajime FujieDepartment of Gastroenterology, Tokyo Shinjuku Medical Center, Tokyo, Japan.
Keiji OguraDepartment of Gastroenterology, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
Hideo YoshidaDepartment of Gastroenterology, Japanese Red Cross Medical Center, Tokyo, Japan.
Tomonori WadaDepartment of Gastroenterology, Sanraku Hospital, Tokyo, Japan.
Kiyohiko KuraiKurai Kiyohiko Medical Clinic, Utsunomiya, Japan.
Hisato MaekawaDepartment of Gastroenterology and Hepatology, Tokyo Takanawa Hospital, Tokyo, Japan.
Shuntaro ObiDepartment of Gastroenterology and Hepatology, Kyoundo Hospital, Tokyo, Japan.
Takuma TerataniDepartment of Hepato-Biliary-Pancreatic medicine, NTT Medical Center Tokyo, Tokyo, Japan.
Naohiko MasakiClinical Laboratory Department, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.
Kayo NagashimaDepartment of Gastroenterology, National Disaster Medical Center, Tachikawa, Japan.
Takashi IshikawaMarunouchi Clinic, Tokyo, Japan.
Naoya KatoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kyoji MoriyaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroshi YotsuyanagiDivision of Infectious Disease and Applied Immunology, The Institute of Medical Science Research Hospital, The University of Tokyo, Tokyo, Japan.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPOgikubo Hospital · JPSanraku Hospital · JPHitachi General Hospital · JPJapanese Red Cross Medical Center · JPJR Tokyo General Hospital · JPKanto Central Hospital · JPMitsui Memorial Hospital · JPNational Center for Global Health and Medicine · JPNational Disaster Medical Center · JPNishikawa Hospital · JPNTT Medical Center · JPShiga University of Medical Science Hospital · JPShowa General Hospital · JPShowa University Fujigaoka Hospital · JPTeikyo University · JPTokyo Metropolitan Police Hospital · JPTokyo Shinagawa Hospital · JPTokyo Teishin Hospital · JPTokyo Yamate Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsIt remains unclear whether obesity increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C who achieved a sustained virological response (SVR) with antiviral therapy.

methodsIn this multicenter cohort study, we enrolled patients with chronic hepatitis C who achieved SVR with interferon (IFN)-based therapy (IFN group) or direct-acting antiviral (DAA) therapy (DAA group) between January 1, 1990, and December 31, 2018. The patients underwent regular surveillance for HCC. Cumulative incidence of and the risk factors for HCC development after SVR were assessed using the Kaplan-Meier method and Cox proportional hazard regression analysis, respectively.

resultsAmong 2,055 patients (840 in the IFN group and 1,215 in the DAA group), 75 developed HCC (41 in the IFN group and 34 in the DAA group) during the mean observation period of 4.1 years. The incidence rates of HCC at 1, 2, and 3 years were 1.2, 1.9, and 3.0%, respectively. Multivariate analysis revealed that in addition to older age, lower albumin level, lower platelet count, higher alpha-fetoprotein level, and absence of dyslipidemia, obesity (body mass index ≥25 kg/m

conclusionsObesity and heavy alcohol consumption increased the risk of HCC development after SVR.

Indexed as

Direct-acting antiviralsHepatitis CHepatocellular carcinomaObesity

Identifiers

PMID34414119
PMCPMC8339497
OpenAlexW3169365416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.