Evidence map›Paper›PMID 34414087›Full record

ArticleInternational journal of ophthalmology2021

Evaluation of axial length/total corneal refractive power ratio as a potential marker for ocular diagnosis of Marfan's syndrome in children.

Tian-Hui Chen, Ai-Zhu Miao, Yu-Liang Wang, Min Zhang, Jia-Hui Chen, Jia-Lei Zheng, Michael Deng, Ying-Hong Ji, Yong-Xiang Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tian-Hui ChenDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Ai-Zhu MiaoDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Yu-Liang WangDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Min ZhangDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Jia-Hui ChenDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Jia-Lei ZhengDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Michael DengDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Ying-Hong JiDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Yong-Xiang JiangDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether the axial length (AL)/total corneal refractive power (TCRP) ratio is a sensitive and simple factor that can be used for the early diagnosis of Marfan's syndrome (MFS) in children.

methodsThe relationship between the AL/TCRP ratio and the diagnosis of MFS for 192 eyes in 97 children were evaluate. The biological characteristics, including age, sex, AL, and TCRP, were collected from medical records. Receiver operating characteristic (ROC) curve analysis was performed to investigate whether the AL/TCRP ratio effectively distinguishes MFS from other subjects. The Youden index was used to re-divide the whole population into two groups according to an AL/TCRP ratio of 0.59.

resultsOf 96 subjects (mean age 7.46±3.28y) evaluated, 56 (110 eyes) had a definite diagnosis of MFS in childhood based on the revised Ghent criteria, 41 (82 eyes) with diagnosis of congenital ectopia lentis (EL) were included as a control group. AL was negatively correlated with TCRP, with a linear regression coefficient of -0.36 (

conclusionAn AL/TCRP ratio of >0.59 is significantly associated with the risk of MFS. The AL/TCRP ratio should be measured as a promising marker for the prognosis of children MFS. Changes in the AL/TCRP ratio should be monitored over time.

Indexed as

axial lengthchildrendiagnosisMarfan's syndrometotal corneal refractive power ratio

Identifiers

PMID34414087
PMCPMC8342285
OpenAlexW3184978840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.