Evidence map›Paper›PMID 34413896›Full record

ArticleComputational and mathematical methods in medicine2021

Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents.

Bing-Hui Li, Jun-Qi Ge, Ya-Li Wang, Li-Jun Wang, Qi Zhang, Cong Bian

Open access · hybridAbstract read
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Review
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  6. Systems andFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bing-Hui LiSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332000, China.
Jun-Qi GeSchool of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Ya-Li WangSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332000, China.ORCID https://orcid.org/0000-0002-3669-3326
Li-Jun WangSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332000, China.
Qi ZhangSchool of Pharmacy and Life Sciences, Jiujiang University, Jiujiang 332000, China.
Cong BianInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
Jiujiang University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNJiangxi University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A ligand-based and docking-based virtual screening was carried out to identify novel MDM2 inhibitors. A pharmacophore model with four features was used for virtual screening, followed by molecular docking. Seventeen compounds were selected for an

Indexed as

Antineoplastic AgentsComputational BiologyDrug DiscoveryDrug Screening Assays, AntitumorEnzyme InhibitorsHCT116 CellsHumansLigandsMCF-7 CellsMolecular Docking SimulationProto-Oncogene Proteins c-mdm2Structure-Activity RelationshipUser-Computer InterfaceAntineoplastic AgentsEnzyme InhibitorsLigandsMDM2 protein, humanProto-Oncogene Proteins c-mdm2

Identifiers

PMID34413896
PMCPMC8369186
OpenAlexW3189415574

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.