Evidence map›Paper›PMID 34413855›Full record

ArticleFrontiers in immunology2021

Cooperation Between Systemic IgG1 and Mucosal Dimeric IgA2 Monoclonal Anti-HIV Env Antibodies: Passive Immunization Protects Indian Rhesus Macaques Against Mucosal SHIV Challenges.

Siqi Gong, Samir K Lakhashe, Dinesh Hariraju, Hanna Scinto, Antonio Lanzavecchia, Elisabetta Cameroni, Davide Corti, Sarah J Ratcliffe, Kenneth A Rogers, Peng Xiao and 3 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siqi GongTexas Biomedical Research Institute, San Antonio, TX, United States.
Samir K LakhasheTexas Biomedical Research Institute, San Antonio, TX, United States.
Dinesh HarirajuTexas Biomedical Research Institute, San Antonio, TX, United States.
Hanna ScintoTexas Biomedical Research Institute, San Antonio, TX, United States.
Antonio LanzavecchiaInstitute for Research in Biomedicine, Bellinzona, Switzerland.
Elisabetta CameroniInstitute for Research in Biomedicine, Bellinzona, Switzerland.
Davide CortiInstitute for Research in Biomedicine, Bellinzona, Switzerland.
Sarah J RatcliffeUniversity of Pennsylvania, Philadelphia, PA, United States.
Kenneth A RogersNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA, United States.
Peng XiaoNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA, United States.
Jane FontenotNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA, United States.
François VillingerNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA, United States.
Ruth M RuprechtTexas Biomedical Research Institute, San Antonio, TX, United States.

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Virology and ImmunologyP01AI048240 · NIAID · UNIVERSITY OF WASHINGTON · PI RUPRECHT, RUTH MARGRIT · 2000 to 2020
$46.7M
NIAID NIH HHS P01 AI048240NIH HHS P51 OD011133
6 · The paper itself

Abstract

Understanding the interplay between systemic and mucosal anti-HIV antibodies can provide important insights to develop new prevention strategies. We used passive immunization

Indexed as

Immunization, PassiveSimian Acquired Immunodeficiency SyndromeAnimalsAntibodies, MonoclonalAntibodies, NeutralizingHIV-1HIV AntibodiesImmunity, MucosalMacaca mulattaPilot ProjectsSimian Immunodeficiency VirusAntibodies, MonoclonalAntibodies, NeutralizingHIV Antibodiesdimeric IgAIgGimmune exclusionpassive mucosal and systemic immunizationrhesus macaque modelSHIV

Identifiers

PMID34413855
PMCPMC8370093

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.