Evidence map›Paper›PMID 34413853›Full record

ArticleFrontiers in immunology2021

The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators.

Ana P Lopes, Cornelis P J Bekker, Maarten R Hillen, Sofie L M Blokland, Anneline C Hinrichs, Aridaman Pandit, Aike A Kruize, Timothy R D J Radstake, Joel A G van Roon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  7. Review
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  11. Defining the Role of Monocytes in Sjögren's Syndrome.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ana P LopesCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Cornelis P J BekkerCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Maarten R HillenCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Sofie L M BloklandCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Anneline C HinrichsCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Aridaman PanditCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Aike A KruizeDepartment of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Timothy R D J RadstakeCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Joel A G van RoonCenter for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
University Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by infiltration of the exocrine glands and prominent B cell hyperactivity. Considering the key role of monocytes in promoting B cell hyperactivity, we performed RNA-sequencing analysis of CD14

Indexed as

AdultAgedAged, 80 and overAutoantibodiesFemaleHumansInflammationInflammation MediatorsInterferon Type ILipopolysaccharide ReceptorsMaleMiddle AgedMonocytesSignal TransductionSjogren's SyndromeToll-Like ReceptorsAutoantibodiesInflammation MediatorsInterferon Type ILipopolysaccharide ReceptorsToll-Like ReceptorsmonocytesSjögren’s syndromesystemic mediatorstranscriptometype-I interferonsWGCNA

Identifiers

PMID34413853
PMCPMC8368727
OpenAlexW3190377900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.