Evidence map›Paper›PMID 34413846›Full record

ArticleFrontiers in immunology2021

Nociceptive Sensory Neurons Mediate Inflammation Induced by

Nicole J Yang, Dylan V Neel, Liwen Deng, Michelle Heyang, Angela Kennedy-Curran, Victoria S Tong, Jin Mo Park, Isaac M Chiu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Skin innervation and itsFrontiers in cellular neuroscience · 2026
    Review
  2. Article
  3. Neuro-immune cross-talk in cancer.Nature reviews. Cancer · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicole J YangDepartment of Immunology, Harvard Medical School, Boston, MA, United States.
Dylan V NeelDepartment of Immunology, Harvard Medical School, Boston, MA, United States.
Liwen DengDepartment of Immunology, Harvard Medical School, Boston, MA, United States.
Michelle HeyangDepartment of Immunology, Harvard Medical School, Boston, MA, United States.
Angela Kennedy-CurranDepartment of Immunology, Harvard Medical School, Boston, MA, United States.
Victoria S TongDepartment of Immunology, Harvard Medical School, Boston, MA, United States.
Jin Mo ParkCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Isaac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA, United States.
Harvard University · USMassachusetts General Hospital · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Training in the Molecular Biology of Neurodegeneration and Alzheimer's DiseaseT32AG000222 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Bruce A YANKNER · 1992 to 2026
$18.5M
Pain and Neuro-immune Signaling in S. pyogenes pathogenesisR01AI130019 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG, WESSELS, MICHAEL R · 2017 to 2021
$3.2M
Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host MicrobiotaDP2AT009499 · NCCIH · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2016 to 2019
$2.7M
NCCIH NIH HHS DP2 AT009499NIAID NIH HHS R01 AI130019NIA NIH HHS T32 AG000222NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

Bacterial products are able to act on nociceptive neurons during pathogenic infection. Neurogenic inflammation is an active part of pain signaling and has recently been shown to impact host-pathogen defense.

Indexed as

AnimalsAnthraxAntigens, BacterialBacillus anthracisBacterial ToxinsInflammationMiceMice, Inbred C57BLNociceptorsanthrax toxinAntigens, BacterialBacterial ToxinsBacillus anthracisedema toxinneurogenic inflammationneuronnociceptors

Identifiers

PMID34413846
PMCPMC8369925
OpenAlexW3190841502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.