ArticlePharmacogenomics and personalized medicine2021
Association Between Insomnia and Migraine Risk: A Case-Control and Bidirectional Mendelian Randomization Study.
Article in Pharmacogenomics and personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Causal factors for migraine in Mendelian randomization studies: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Circadian Features of Cluster Headache and Migraine: A Systematic Review, Meta-analysis, and Genetic Analysis.Neurology · 2023Pooled it
- Mechanistic Overlaps Between Sleep and Headache Disorders: From Dopaminergic Dysfunction to Neuroinflammation-A Narrative Review.Clocks & sleep · 2026Review
- Interaction between physical frailty and sleep quality on risk of migraine in later life: a cohort study of over 350,000 participants.BMC public health · 2025Article
- Burden of migraine among university students in the Middle East and North Africa: a cross-sectional study of prevalence, mental health comorbidities, and disability.BMC public health · 2025Article
- Mendelian randomization studies on the causal relationship between insomnia and disease.Frontiers in medicine · 2025Review
- Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study.Journal of immunology research · 2024Article
- Association between risk factors and migraine in Pakistani females.BMC women's health · 2023Article
- Selection of genetic instruments in Mendelian randomisation studies of sleep traits.Sleep medicine · 2023Review
- Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study.BMC cancer · 2023Article
- Investigating the relationship between sleep and migraine in a global sample: a Bayesian cross-sectional approach.The journal of headache and pain · 2023Article
- Noncausal effects between tea intake and migraine risk: a Mendelian randomization study.Scientific reports · 2023Article
- Genetics of migraine: where are we now?The journal of headache and pain · 2023Review
- Income dissatisfaction and migraine headache. Evidence from a nationwide population-based survey.Health psychology and behavioral medicine · 2023Article
- Exploring genetic association of insomnia with allergic disease and asthma: a bidirectional Mendelian randomization study.Respiratory research · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe causal relationship between insomnia and migraine is contradictory and no study has been carried out among the Chinese population to date.
methodsIn this case, we conducted a case-control study and a bidirectional mendelian randomization (MR) analysis to determine whether insomnia is causally related to the development of migraine. The instrumental variables for insomnia were derived from the largest genome-wide association study of 1,331,010 participants, while the genetic instruments for migraine were available from the largest meta-analysis of migraine with 59,674 cases and 316,078 controls.
resultsIn case-control study, subjects with insomnia have significantly higher risk of migraine (OR=4.29, 95% CI: 3.21-5.74, P<0.001), compared with those without insomnia. The bidirectional two-sample MR analysis revealed that insomnia was significantly associated with higher risk of migraine (OR=1.24, 95% CI: 1.11-1.38, P=1.01×10-4), and the results were validated in the UK Biobank data. The results showed no indication for directional pleiotropy effects as assessed by the MR-Egger intercept (P>0.05).
conclusionConclusively, our study highlighted that increased migraine risk was confined to subjects with a genetic pre-disposition to insomnia, and these findings had potential implications for improving the sleep quality to reduce the burden of migraine.
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