ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2021
Assessment of Microcirculation in the Type 2 Diabetic and Impaired Glucose Tolerance Feet of Elderly Men by CEUS.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Correlation Analysis of Lower Limb Contrast-Enhanced Ultrasound Findings With Serum VEGF and CXCL-12 Levels in a Rabbit Model of Diabetic Foot.BioMed research international · 2026Article
- Early detection of retinal and choroidal microvascular impairments in diabetic patients with myopia.Frontiers in cell and developmental biology · 2025Article
- Microcirculatory disturbances in type 2 diabetes: early detection using laser doppler flowmetry for personalized care.Frontiers in endocrinology · 2025Observational
- [Preliminary Application of Contrast-Enhanced Ultrasound in the Treatment of Diabetic Ulcers].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the foot microcirculation in type 2 diabetes mellitus (T2DM) and impaired glucose tolerance patients (IGT) with contrast-enhanced ultrasound (CEUS).
methodsThe study included 37 patients with T2DM but without diabetic foot (DM group), 15 patients with impaired glucose tolerance (IGT group) and 10 elderly males with normal fasting blood glucose (FBS) and negative glucose tolerance tests (control group). Color Doppler flow imaging (CDFI) and CEUS were performed on the right foot great toes for detecting the blood perfusion performance. CEUS images were recorded and parameters of CDFI and flow time-intensity curves (TICs) were analyzed by the Student's
resultsThere was no significant difference in CDFI parameters pulse index and peak systolic blood flow velocity (PSV) among the three groups (P >0.05). Compared with control group, CEUS images of IGT and DM groups showed lower microvascular density and were pale. Peak intensity (PI) and area under time-intensity curve (AUC) in control, IGT and DM groups were decreased gradually (PI 46.36±10.96 vs 35.26±11.65 vs 28.15±7.94, P = 0.001, AUC 5.12±1.02 vs 3.25±1.60 vs 2.81±1.20, P = 0.001). The arrival times (AT) and time to peak (TTP) tended to be increased with the extension of DM course, but the difference was not statistically significant (AT, P = 0.260, TTP, P = 0.481).
conclusionCEUS, as a noninvasive and valuable technique, could detect the alterations in foot microcirculation of DM and IGT patients.
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