Evidence map›Paper›PMID 34413470›Full record

ArticleBone marrow transplantation2022

A SAS macro for estimating direct adjusted survival functions for time-to-event data with or without left truncation.

Zhen-Huan Hu, Hai-Lin Wang, Robert Peter Gale, Mei-Jie Zhang

Erratum issuedOpen access · bronzeAbstract readEditorial
In one paragraph

Article in Bone marrow transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Zhen-Huan HuMedical College of Wisconsin, Milwaukee, WI, USA. novelkeny@gmail.com.ORCID http://orcid.org/0000-0002-3303-8991
Hai-Lin WangEverest Clinical Research Services, Inc., Little Falls, NJ, USA.
Robert Peter GaleImperial College London, London, UK.
Mei-Jie ZhangMedical College of Wisconsin, Milwaukee, WI, USA.
Medical College of Wisconsin · USImperial College London · GB

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Department of HealthNCI NIH HHS U24 CA076518
6 · The paper itself

Abstract

There are several statistical programmes to compute direct adjusted survival estimates from results of the Cox proportional hazards model. However, when used to analyze observational databases with large sample sizes or highly stratified treatment groups such as in registry-related datasets, these programmes are inefficient or unable to generate confidence bands and simultaneous p values. Also, these programmes do not consider potential left-truncation in retrospectively collected data. To address these deficiencies we developed a new SAS macro %adjsurvlt() able to produce direct adjusted survival estimates based on a stratified Cox model. The macro has improved computational performance and is able to handle left-truncated and right-censored time-to-event data. Several mechanisms were implemented to improve computational efficiency including choosing matrix operations over do-loops and reducing dimensions of co-variate matrices. Compared to the latest SAS macro, %adjsurvlt() used < 0.1% computational time to process a dataset with 100 treatment cohorts and a sample size of 20,000 and showed similar computational efficiency when analyzing left-truncated and right-censored data. We illustrate use of %adjsurvlt() to compare retrospectively collected survival data of 2 transplant cohorts.

Indexed as

Retrospective StudiesHumansProportional Hazards ModelsSample SizeSurvival Analysis

Identifiers

PMID34413470
PMCPMC9396933
OpenAlexW3195081024

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.