Evidence map›Paper›PMID 34413455›Full record

ArticleCommunications biology2021

Consistent tumorigenesis with self-assembled hydrogels enables high-powered murine cancer studies.

Abigail K Grosskopf, Santiago Correa, Julie Baillet, Caitlin L Maikawa, Emily C Gale, Ryanne A Brown, Eric A Appel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Abigail K GrosskopfDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0471-1825
Santiago CorreaDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Julie BailletDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4670-5762
Caitlin L MaikawaDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6214-1226
Emily C GaleDepartment of Biochemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6536-3027
Ryanne A BrownDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9099-7227
Eric A AppelDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu.ORCID 0000-0002-2301-7126
Stanford University · USCardiovascular Institute of the South · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical cancer research is heavily dependent on allograft and xenograft models, but current approaches to tumor inoculation yield inconsistent tumor formation and growth, ultimately wasting valuable resources (e.g., animals, time, and money) and limiting experimental progress. Here we demonstrate a method for tumor inoculation using self-assembled hydrogels to reliably generate tumors with low variance in growth. The observed reduction in model variance enables smaller animal cohorts, improved effect observation and higher powered studies.

Indexed as

CarcinogenesisDisease Models, AnimalHydrogelsAnimalsHeterograftsMiceHydrogels

Identifiers

PMID34413455
PMCPMC8376877
OpenAlexW3195094921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.