Evidence map›Paper›PMID 34413405›Full record

ArticleScientific reports2021

Evaluation of the feasibility of explainable computer-aided detection of cardiomegaly on chest radiographs using deep learning.

Mu Sook Lee, Yong Soo Kim, Minki Kim, Muhammad Usman, Shi Sub Byon, Sung Hyun Kim, Byoung Il Lee, Byoung-Dai Lee

Abstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mu Sook Lee *Department of Radiology, Keimyung University Dongsan Hospital, 1035, Dalgubeol-daero, Sindang-dong, Daegu, 42601, Republic of Korea.
Yong Soo Kim *Division of ICT Convergence, Kyonggi University, 154-42, Gwanggyosan-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16227, Republic of Korea.
Minki KimDivision of AI Computer Science and Engineering, Kyonggi University, 154-42, Gwanggyosan-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16227, Republic of Korea.
Muhammad UsmanCenter for Artificial Intelligence in Medicine and Imaging, HealthHub, Co. Ltd., 623, Gangnam-daero, Seocho-gu, Seoul, 06524, Republic of Korea.
Shi Sub ByonCenter for Artificial Intelligence in Medicine and Imaging, HealthHub, Co. Ltd., 623, Gangnam-daero, Seocho-gu, Seoul, 06524, Republic of Korea.
Sung Hyun KimHuman Medical Imaging and Intervention Center, 621, Gangnam-daero, Seocho-gu, Seoul, 06524, Republic of Korea.
Byoung Il LeeCenter for Artificial Intelligence in Medicine and Imaging, HealthHub, Co. Ltd., 623, Gangnam-daero, Seocho-gu, Seoul, 06524, Republic of Korea.
Byoung-Dai LeeDivision of AI Computer Science and Engineering, Kyonggi University, 154-42, Gwanggyosan-ro, Yeongtong-gu, Suwon, Gyeonggi-do, 16227, Republic of Korea. blee@kgu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the feasibility of explainable computer-aided detection of cardiomegaly in routine clinical practice using segmentation-based methods. Overall, 793 retrospectively acquired posterior-anterior (PA) chest X-ray images (CXRs) of 793 patients were used to train deep learning (DL) models for lung and heart segmentation. The training dataset included PA CXRs from two public datasets and in-house PA CXRs. Two fully automated segmentation-based methods using state-of-the-art DL models for lung and heart segmentation were developed. The diagnostic performance was assessed and the reliability of the automatic cardiothoracic ratio (CTR) calculation was determined using the mean absolute error and paired t-test. The effects of thoracic pathological conditions on performance were assessed using subgroup analysis. One thousand PA CXRs of 1000 patients (480 men, 520 women; mean age 63 ± 23 years) were included. The CTR values derived from the DL models and diagnostic performance exhibited excellent agreement with reference standards for the whole test dataset. Performance of segmentation-based methods differed based on thoracic conditions. When tested using CXRs with lesions obscuring heart borders, the performance was lower than that for other thoracic pathological findings. Thus, segmentation-based methods using DL could detect cardiomegaly; however, the feasibility of computer-aided detection of cardiomegaly without human intervention was limited.

Indexed as

Deep LearningDiagnosis, Computer-AssistedAdolescentAdultAgedAged, 80 and overArea Under CurveCardiomegalyChildFeasibility StudiesFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedNeural Networks, Computer

Identifiers

PMID34413405
PMCPMC8376868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.