ArticleScientific reports2021
Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Shedding Light on Interaction Between Neurological Symptoms and Psychiatric Episodes in Multiple Sclerosis: Novel Hypothesis and Therapeutic Avenues.Molecular neurobiology · 2026Review
- Investigating the association between grey matter hypoperfusion and atrophy in multiple sclerosis using arterial spin labelling.Brain communications · 2026Article
- Cognitive outcomes in multiple sclerosis are shaped by divergent functional connectivity trajectories.Brain communications · 2026Article
- Structural and diffusion imaging in olfactory-related brain regions in Parkinson's disease: predictors of clinical progression.Scientific reports · 2025Article
- Unraveling Microstructural and Macrostructural Brain Age Dynamics in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Topological abnormalities of the morphometric similarity network of the cerebral cortex in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis.Annals of clinical and translational neurology · 2024Article
- The cognitive relevance of non-lesional damage to cortical networks in people with multiple sclerosis.Journal of neurology · 2024Article
- Predicting disease severity in multiple sclerosis using multimodal data and machine learning.Journal of neurology · 2024Article
- Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study.Journal of translational medicine · 2024Article
- Longitudinal network-based brain grey matter MRI measures are clinically relevant and sensitive to treatment effects in multiple sclerosis.Brain communications · 2024Article
- Multimodal Investigation of Deep Gray Matter Nucleus in Patients with Multiple Sclerosis and Their Clinical Correlations: A Multivariate Pattern Analysis Study.Journal of personalized medicine · 2023Article
- Neuroimmune, clinical and treatment challenges in multiple sclerosis-related psychoses.World journal of psychiatry · 2023Review
- Diffusion tensor imaging metrics associated with future disability in multiple sclerosis.Scientific reports · 2023Article
- Synapse Dysfunctions in Multiple Sclerosis.International journal of molecular sciences · 2023Review
- Detection of grey matter microstructural substrates of neurodegeneration in multiple sclerosis.Brain communications · 2023Article
- Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation.Frontiers in neurology · 2023Review
- Changes in diffusion tensor imaging indices in basal ganglia and thalamus of patients with Relapsing-Remitting Multiple Sclerosis and relation with clinical conditions: A case-control study.European journal of radiology open · 2023Article
- Applying multilayer analysis to morphological, structural, and functional brain networks to identify relevant dysfunction patterns.Network neuroscience (Cambridge, Mass.) · 2022Article
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19 authors.
Funding
Abstract
The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications of microstructure, and we quantified volume loss in GM in a cohort of patients with MS classified into three groups according to disease duration. Additionally, we investigated the relationship between GM changes with disease severity. We studied 54 healthy controls and 247 MS patients classified regarding disease duration: MS1 (less than 5 years, n = 67); MS2 (5-15 years, n = 107); and MS3 (more than15 years, n = 73). We compared GM mean diffusivity (MD), fractional anisotropy (FA) and volume between groups, and estimated their clinical associations. Regional modifications in diffusion measures (MD and FA) and volume did not overlap early in the disease, and became widespread in later phases. We found higher MD in MS1 group, mainly in the temporal cortex, and volume reduction in deep GM and left precuneus. Additional MD changes were evident in cingulate and occipital cortices in the MS2 group, coupled to volume reductions in deep GM and parietal and frontal poles. Changes in MD and volume extended to more than 80% of regions in MS3 group. Conversely, increments in FA, with very low effect size, were observed in the parietal cortex and thalamus in MS1 and MS2 groups, and extended to the frontal lobe in the later group. MD and GM changes were associated with white matter lesion load and with physical and cognitive disability. Microstructural integrity loss and atrophy present differential spatial predominance early in MS and accrual over time, probably due to distinct pathogenic mechanisms that underlie tissue damage.
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