Evidence map›Paper›PMID 34413324›Full record

ArticleScientific reports2021

Machine learning approach to dynamic risk modeling of mortality in COVID-19: a UK Biobank study.

Mohammad A Dabbah, Angus B Reed, Adam T C Booth, Arrash Yassaee, Aleksa Despotovic, Benjamin Klasmer, Emily Binning, Mert Aral, David Plans, Davide Morelli and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
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  11. Review
  12. Learning and Predicting from Dynamic Models for COVID-19 Patient Monitoring.Statistical science : a review journal of the Institute of Mathematical Statistics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Mohammad A DabbahHuma Therapeutics Limited, London, UK.
Angus B ReedHuma Therapeutics Limited, London, UK.
Adam T C BoothHuma Therapeutics Limited, London, UK.
Arrash YassaeeHuma Therapeutics Limited, London, UK.
Aleksa DespotovicHuma Therapeutics Limited, London, UK.
Benjamin KlasmerHuma Therapeutics Limited, London, UK.
Emily BinningHuma Therapeutics Limited, London, UK.
Mert AralHuma Therapeutics Limited, London, UK.
David PlansHuma Therapeutics Limited, London, UK. david.plans@huma.com.
Davide MorelliHuma Therapeutics Limited, London, UK.
Alain B LabriqueJohns Hopkins Bloomberg School Public Health, Baltimore, MD, USA.
Diwakar MohanJohns Hopkins Bloomberg School Public Health, Baltimore, MD, USA.
Bloomberg (United States) · USImperial College London · GBUniversity of Belgrade · RSUniversity of Exeter · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

The COVID-19 pandemic has created an urgent need for robust, scalable monitoring tools supporting stratification of high-risk patients. This research aims to develop and validate prediction models, using the UK Biobank, to estimate COVID-19 mortality risk in confirmed cases. From the 11,245 participants testing positive for COVID-19, we develop a data-driven random forest classification model with excellent performance (AUC: 0.91), using baseline characteristics, pre-existing conditions, symptoms, and vital signs, such that the score could dynamically assess mortality risk with disease deterioration. We also identify several significant novel predictors of COVID-19 mortality with equivalent or greater predictive value than established high-risk comorbidities, such as detailed anthropometrics and prior acute kidney failure, urinary tract infection, and pneumonias. The model design and feature selection enables utility in outpatient settings. Possible applications include supporting individual-level risk profiling and monitoring disease progression across patients with COVID-19 at-scale, especially in hospital-at-home settings.

Indexed as

Models, StatisticalAgedAged, 80 and overBiological Specimen BanksCohort StudiesComorbidityCOVID-19FemaleHumansMachine LearningMaleMiddle AgedPandemicsPrognosisRisk FactorsSARS-CoV-2

Identifiers

PMID34413324
PMCPMC8376891
OpenAlexW3153252530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.