ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- The role of the kynurenine pathway in conditioned place aversion induced by synthetic cannabinoid CP-55940.Behavioral and brain functions : BBF · 2026Article
- CB2R-mediated GPX4 stabilization: a new avenue for treating cognitive impairment in elderly migraine patients.The journal of headache and pain · 2026Article
- Review
- Chemogenetic silencing reveals presynaptic GiScience · 2024Article
- Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies.Neural regeneration research · 2024Review
- Protein Kinase A-Dependent Plasticity of Local Inhibitory Synapses from Hilar Somatostatin-Expressing Neurons.eNeuro · 2023Article
- CB1R blockade unmasks TRPV1-mediated contextual fear generalization in female, but not male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Estimation of cAMP binding in hippocampus CA1 field by a fluorescent probe.Frontiers in cell and developmental biology · 2023Article
- Imaging the endocannabinoid signaling system.Journal of neuroscience methods · 2022Review
- Chemogenetic Silencing of Differentiating Cortical Neurons Impairs Dendritic and Axonal Growth.Frontiers in cellular neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experience-dependent formation and removal of inhibitory synapses are essential throughout life. For instance, GABAergic synapses are removed to facilitate learning, and strong excitatory activity is accompanied by the formation of inhibitory synapses to maintain coordination between excitation and inhibition. We recently discovered that active dendrites trigger the growth of inhibitory synapses via CB1 receptor-mediated endocannabinoid signaling, but the underlying mechanism remained unclear. Using two-photon microscopy to monitor the formation of individual inhibitory boutons in hippocampal organotypic slices from mice (both sexes), we found that CB1 receptor activation mediated the formation of inhibitory boutons and promoted their subsequent stabilization. Inhibitory bouton formation did not require neuronal activity and was independent of G
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Registered trials
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