Evidence map›Paper›PMID 34413139›Full record

ArticleScience immunology2021

Autoantibodies neutralizing type I IFNs are present in

Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Jérémy Manry, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat and 191 more

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 400 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
400citing papers in PubMed, 3 pooled it
34.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06510426 phase2unknown statusnot on this mapstarted 2024, after this paper: background citation

Early Interferon-beta Treatment for West-Nile Virus Infection

TypeinterventionalSponsorTel-Aviv Sourasky Medical CenterRan2024 to 2025Enrolled100ConditionsWest Nile Virus, West Nile Fever Encephalitis, West Nile Fever Myelitis, West Nile Fever With Other ComplicationsArmsRebif 44 MCG Per 0.5 ML Prefilled Syringe, Saline
NCT06762002 recruitingnot on this mapstarted 2025, after this paper: background citation

Impaired Type I IFN Immunity Due to Autoantibodies or a Genetic Defect: a Prospective National Cohort

Typeobservational_patient_registrySponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2025 to 2029Enrolled500ConditionsImmunology, Allergy, Genetic Diseases, Infectious DiseasesArmsblood sample
3 · Its place in the literature

Who cites it

400 citing papers in PubMed, 3 syntheses or guidelines pooled it, 617 citations in OpenAlex.

  1. Pooled it
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  12. Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Observational
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340 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

201 authors at 20 institutions in 29 countries.

Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. jean-laurent.casanova@rockefeller.edu paul.bastard@institutimagine.org.
Adrian Gervais *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Tom Le Voyer *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Jérémie Rosain *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Quentin Philippot *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Jérémy Manry *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Eleftherios Michailidis *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Hans-Heinrich Hoffmann *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Shohei Eto *Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Marina Garcia-Prat *Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.
Lucy Bizien *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Alba Parra-Martínez *Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.
Rui Yang *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Liis Haljasmägi *Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Mélanie Migaud *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Karita Särekannu *Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Julia Maslovskaja *Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Nicolas de ProstService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique - Hôpitaux de Paris (AP-HP).
Yacine Tandjaoui-LambiotteAvicenne Hospital, Assistance Publique Hôpitaux de Paris, Bobigny, INSERM U1272 Hypoxia & Lung, Bobigny, France.
Charles-Edouard LuytSorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Médecine Intensive Réanimation, AP-HP, Paris, France.
Blanca Amador-BorreroInternal Medicine Department, Lariboisière Hospital, AP-HP, Paris University, Paris, France.
Alexandre GaudetUniversity of Lille, U1019-UMR9017-Center for Infection and Immunity of Lille, Lille, France.
Julien PoissyUniversity of Lille, U1019-UMR9017-Center for Infection and Immunity of Lille, Lille, France.
Pascal MorelEtablissement Français du Sang, La Plaine-St Denis, France.
Pascale RichardEtablissement Français du Sang, La Plaine-St Denis, France.
Fabrice CognasseSAINBIOSE, INSERM U1059, University of Lyon, Université Jean-Monnet-Saint-Etienne.
Jesus TroyaDepartment of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain.
Sophie Trouillet-AssantHospices Civils de Lyon, Lyon, France; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.
Alexandre BelotJoint Research Unit, Hospices Civils de Lyon-bio Mérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.
Kahina SakerJoint Research Unit, Hospices Civils de Lyon-bio Mérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.
Pierre GarçonIntensive Care Unit, Grand Hôpital de l'Est Francilien Site de Marne-la-Vallée, Jossigny, France.
Jacques G RivièrePediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.
Jean-Christophe LagierInstitut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
Stéphanie GentileService d'Evaluation Médicale, Hôpitaux Universitaires de Marseille Assistance Publique Hôpitaux de Marseille (APHM), Marseille, France.
Lindsey B RosenLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Elana ShawLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Tomohiro MorioDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Junko TanakaDepartment of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
David DalmauHospital Universitari Mutua Tarrassa, Tarrasa, Spain.
Pierre-Louis TharauxParis Cardiovascular Center, PARCC, Inserm, Université de Paris, Paris, France.
Damien SeneInternal Medicine Department, Lariboisière Hospital, AP-HP, Paris University, Paris, France.
Alain StepanianService d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris and EA3518, Institut Universitaire d'Hématologie-Hôpital Saint Louis, Université Paris Diderot, Paris, France.
Bruno MegarbaneRéanimation Médicale et Toxicologique, Hôpital Lariboisière (AP-HP), Université Paris-Diderot, INSERM Unité Mixte de Recherche Scientifique (UMRS) 1144.
Vasiliki TriantafylliaLaboratory of Immunobiology, Center for Clinical, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Arnaud FekkarLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
James R HeathInstitute for Systems Biology, Seattle, WA 98109, USA.
José Luis FrancoPrimary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UDEA, Medellín, Colombia.
Juan-Manuel AnayaCenter for Autoimmune Disease Research, School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
Jordi Solé-ViolánCritical Care Unit, University Hospital of Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Canary Islands, Spain.
Luisa ImbertiCREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Andrea BiondiPediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.
Paolo BonfantiDepartment of Infectious Diseases, San Gerardo Hospital-University of Milano-Bicocca, Monza, Italy.
Riccardo CastagnoliLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Yu ZhangLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Andrew L SnowDepartment of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Steven M HollandLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Catherine BiggsDepartment of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.
Marcela Moncada-VélezSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Andrés Augusto AriasSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Lazaro LorenzoLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Soraya BoucheritLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Boubacar CoulibalyLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Dany AnglicheauDepartment of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.
Anna M PlanasInstitute for Biomedical Research, Spanish Research Council, Barcelona, Spain.
Filomeen HaerynckDepartment of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium.
Sotirija DuvlisFaculty of Medical Sciences, University "Goce Delchev", Stip, Republic of Northern Macedonia.
Robert L NussbaumCancer Genetics and Prevention Program, University of California San Francisco, San Francisco, USA.
Tayfun OzcelikDepartment of Molecular Biology and Genetics, Bilkent University, Bilkent - Ankara, Turkey.
Sevgi KelesMeram Medical Faculty, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey.
Ahmed A BousfihaClinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Jalila El BakkouriClinical Immunology Unit, Department of Pediatric Infectious Disease, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Carolina Ramirez-SantanaPrimary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia UDEA, Medellín, Colombia.
Stéphane PaulDepartment of Immunology, CIC1408, GIMAP CIRI INSERM U1111, University Hospital of Saint-Etienne, Saint-Etienne, France.
Qiang Pan-HammarströmDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Lennart HammarströmDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Annabelle DupontUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, France.
Alina KurolapThe Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
Christine N MetzFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Alessandro AiutiPathogenesis and Therapy of Primary Immunodeficiencies Unit, San Raffaele, Milano, Italy.
Giorgio CasariPathogenesis and Therapy of Primary Immunodeficiencies Unit, San Raffaele, Milano, Italy.
Vito LampasonaDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Fabio CiceriHematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
Lucila A BarreirosDepartment of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Elena Dominguez-GarridoFundación Rioja Salud - Centro de Investigación Biomédica de La Rioja, Logrono, Spain.
Mateus VidigalUniversity of Sao Paulo, Sao Paulo, Brazil.
Mayana ZatzUniversity of Sao Paulo, Sao Paulo, Brazil.
Diederik van de BeekDepartment of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands.
Sabina SahanicDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Ivan TancevskiDepartment of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Yurii StepanovskyyShupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
Oksana BoyarchukDepartment of Children's Diseases and Pediatric Surgery, I.Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Yoko NukuiDepartment of Infection Control and Prevention, Medical Hospital, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Miyuki TsumuraDepartment of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Loreto VidaurIntensive Care Department, Donostia University Hospital, San Sebastian, Spain.
Stuart G TangyeGarvan Institute of Medical Research, Sydney, Australia.
Sonia BurrelSorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié Salpêtrière, Service de Virologie, Paris, France.
Darragh DuffyTranslational Immunology Lab, Institut Pasteur.
Lluis Quintana-MurciHuman Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, Paris, France.
Adam KlocperkDepartment of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, Prague, Czech Republic.
Nelli Y KannDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Anna ShcherbinaDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Yu-Lung LauDepartment of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
Daniel LeungDepartment of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong, China.
Matthieu CoulongeatDivision of Geriatric Medicine, Tours University Medical Center, Tours, France.
Julien MarletINSERM U1259, MAVIVH, Université de Tours, Tours, France.
Rutger KoningDepartment of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands.
Luis Felipe ReyesDepartment of Microbiology, Universidad de La Sabana, Chia, Colombia.
Angélique Chauvineau-GrenierService de Biologie Médicale, CHI Robert Ballanger, Aulnay sous Bois, France.
Fabienne VenetLaboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.
Guillaume MonneretLaboratoire d'Immunologie, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.
Michel C NussenzweigLaboratory of Molecular Immunology, Rockefeller University, New York, NY, USA.
Romain ArrestierService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique - Hôpitaux de Paris (AP-HP).
Idris BoudhabhayDepartment of Nephrology and Transplantation, Necker University Hospital - APHP, Paris, France; INEM INSERM U 1151- CNRS UMR 8253, Paris University, Paris, France.
Hagit Baris-FeldmanThe Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
David HaginSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Joost WautersMedical Intensive care Unit, University Hospitals Leuven, Leuven, Belgium.
Isabelle MeytsLaboratory of Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, KU Leuven, Leuven, Belgium.
Adam H DyerDepartment of Age-Related Healthcare, Tallaght University Hospital & Department of Medical Gerontology, School of Medicine, Trinity College Dublin.
Sean P KennellyDepartment of Age-Related Healthcare, Tallaght University Hospital & Department of Medical Gerontology, School of Medicine, Trinity College Dublin.
Nollaig M BourkeDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin.
Rabih HalwaniSharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Narjes Saheb Sharif-AskariSharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Karim DorghamSorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, (CIMI- Paris), Paris, France.
Jérome SalletteCerba Health Care, Issy-les-Moulineaux, France.
Souad Mehlal SedkaouiCerba Health Care, Issy-les-Moulineaux, France.
Suzan AlKhaterDepartment of Pediatrics, King Fahad Hospital of the University, Al-Khobar, Saudi Arabia.
Raúl Rigo-BonninDepartment of Clinical Laboratory, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.
Francisco MorandeiraDepartment of Immunology, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.
Lucie RousselDepartment of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.
Donald C VinhDepartment of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.
Sisse Rye OstrowskiDepartment of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Antonio Condino-NetoDepartment of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Carolina PrandoFaculdades Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil.
Anastasiia BonradenkoShupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
András N SpaanSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laurent GilardinService de Médecine Interne, Hôpital universitaire Jean-Verdier, AP-HP, Bondy, France.
Jacques FellaySchool of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Stanislas LyonnetImagine Institute, Université de Paris, INSERM UMR 1163, Paris, France.
Kaya BilguvarYale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.
Richard P LiftonYale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.
Shrikant ManeDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
HGID Lab
COVID Clinicians
COVID-STORM Clinicians
NIAID Immune Response to COVID Group
NH-COVAIR Study Group
Danish CHGE
Danish Blood Donor Study
St. James's Hospital
SARS CoV2 Interest group
French COVID Cohort Study Group
Imagine COVID-Group
Milieu Intérieur Consortium
CoV-Contact Cohort
Amsterdam UMC Covid-19
Biobank Investigators
COVID Human Genetic Effort
CONSTANCES cohort
3C-Dijon Study
Cerba Health-Care
Etablissement du Sang study group
Mark S AndersonDiabetes Center, University of California, San Francisco, CA, USA.
Bertrand BoissonLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Vivien BéziatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Shen-Ying ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Evangelos Vandreakos *Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Olivier Hermine *University of Paris, Imagine Institute, Paris, France.
Aurora Pujol *Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, and Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain.
Pärt Peterson *Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Trine H Mogensen *Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.
Lee Rowen *Institute for Systems Biology, Seattle, WA 98109, USA.
James Mond *ADMA Biologics Inc., Ramsey NJ.
Stéphanie DebetteUniversity of Bordeaux, INSERM, Bordeaux Population Health Center, UMR1219, F-33000 Bordeaux, France.
Xavier de Lamballerie *IHU Méditerranée Infection, Unité des Virus Émergents, UVE: Aix Marseille University, IRD 190, INSERM 1207, Marseille, France.
Xavier Duval *Inserm CIC 1425, Paris, France.
France Mentré *Inserm CIC 1425, Paris, France.
Marie Zins *Université de Paris, Université Paris-Saclay, UVSQ, Inserm UMS11, Villejuif, France.
Pere Soler-Palacin *Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain.
Roger Colobran *Immunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, UAB, Barcelona, Catalonia, Spain.
Guy Gorochov *Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, (CIMI- Paris), Paris, France.
Xavier Solanich *Department of Internal Medicine, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain.
Sophie Susen *Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000 Lille, France.
Javier Martinez-Picado *IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain.
Didier Raoult *Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
Marc Vasse *Service de Biologie Clinique & UMR-S 1176, Hopital Foch, Suresnes, France.
Peter K Gregersen *Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Lorenzo Piemonti *Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Carlos Rodríguez-Gallego *Hospital Universitario de Gran Canaria Dr Negrín, Canarian Health System, Canary Islands, Spain.
Luigi D Notarangelo *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Helen C Su *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.
Kai Kisand *Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Satoshi Okada *Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Anne Puel *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Emmanuelle Jouanguy *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Charles M Rice *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Pierre Tiberghien *Etablissement Français du Sang, La Plaine-St Denis, France.
Qian Zhang *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Aurélie Cobat *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Laurent Abel *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Jean-Laurent Casanova *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. jean-laurent.casanova@rockefeller.edu paul.bastard@institutimagine.org.
Inserm · FRUniversité Claude Bernard Lyon 1 · FROffice of Extramural Research · USCentre National de la Recherche Scientifique · FRHebron University · PSHiroshima University · JPRockefeller University · USUniversity of Tartu · EEUniversidade de São Paulo · BRBellvitge University Hospital · ESInstitute for Systems Biology · USNorthwell Health · USTrinity College Dublin · IEUniversidad de Antioquia · COVita-Salute San Raffaele University · ITAarhus University · DKAcademy of Athens · GRAmsterdam Neuroscience · NLAssistance Publique – Hôpitaux de Paris · FRDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RU

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Understanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI RAVETCH, JEFFREY VICTOR · 2014 to 2023
$26.0M
Yale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8M
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6 · The paper itself

Abstract

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, NeutralizingAutoantibodiesCase-Control StudiesChildChild, PreschoolCOVID-19Critical IllnessHumansImmunoglobulin GInfantInfant, NewbornInterferon-alphaAntibodies, NeutralizingAutoantibodiesImmunoglobulin GInterferon-alphainterferon omega 1Interferon Type I

Identifiers

PMID34413139
PMCPMC8521484
OpenAlexW3195130348

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