ArticleBMJ case reports2021
Not all that is 'full house' is systemic lupus erythematosus: a case of membranous nephropathy due to syphilis infection.
Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Systemic Lupus Erythematosus with Nephritis: a Macrophage Activation Syndrome Heralding a New Disease Difficult to Diagnose.Mediterranean journal of hematology and infectious diseases · 2026Article
- A case of syphilis-associated membranous nephropathy with NDNF detected by immunohistochemistry, not by mass spectrometry: case report and literature review.CEN case reports · 2025Review
- Target Antigens of Membranous Nephropathy With Syphilis Infection.Kidney international reports · 2024Article
- Rapid Remission of Secondary Membranous Glomerulonephritis Due to Syphilis: A Case Report.Cureus · 2023Article
- A rare cause of full-house membranous glomerulopathy in an infant: Answers.Pediatric nephrology (Berlin, Germany) · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
We describe an unusual case of membranous nephropathy precipitated by syphilis infection in a patient without systemic lupus erythematosus (SLE). A previously healthy 20-year-old man presented with leg and facial swelling. Laboratory investigation revealed nephrotic range proteinuria, acute kidney injury, hypocomplementaemia and a highly positive rapid plasma reagin. Kidney biopsy showed membranous nephropathy with 'full-house' immunofluorescence (IgG, IgA, IgM, C1q and C3), mimicking lupus nephritis class Vb. However, the patient had no features of SLE and had negative antinuclear and anti-double-stranded DNA antibodies. He was treated with high-dose methylprednisolone and mycophenolate mofetil for lupus nephritis and with penicillin for syphilis. After 2 months of therapy, his proteinuria resolved, and his renal function and C4 level normalised. This case illustrates that syphilis infection can be a mimicker of lupus nephritis. A literature review suggests that ful-house nephropathy may occur independently of lupus nephritis and may or may not develop into SLE.
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