Evidence map›Paper›PMID 34413037›Full record

ArticleBMJ case reports2021

Fatal tuberculous meningitis in an infant presenting with seizures in the UK.

Nisreen Khambati, Mimi Hou, Dominic Kelly, Rinn Song

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Nisreen KhambatiDepartment of Paediatrics, Buckinghamshire Healthcare NHS Trust, Amersham, Buckinghamshire, UK nisreen.khambati@conted.ox.ac.uk.ORCID http://orcid.org/0000-0003-2693-3266
Mimi HouThe Jenner Institute, University of Oxford, Oxford, UK.
Dominic KellyDepartment of Paediatrics, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, UK.
Rinn SongOxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, Oxfordshire, UK.
University of Oxford · GBBuckinghamshire Healthcare NHS Trust · GBOxford BioMedica (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 5-month-old male child of European background presented with sudden onset of prolonged afebrile seizures. He was intubated and transferred to the paediatric intensive care unit where he displayed abnormal neurology and remained ventilated. Brain MRI showed basal leptomeningeal enhancement suggesting malignancy or infection. Subsequent cerebrospinal fluid results of lymphocytic pleocytosis and raised protein were suggestive of tuberculous (TB) meningitis and anti-TB treatment was commenced empirically. Positive TB microbiology was eventually confirmed on respiratory secretions. The infant continued to show abnormal neurologic findings and repeated neuroimaging showed a new extensive cerebral infarct. The infant was compassionately extubated and passed away. The father was later found to have pulmonary TB. This case is an important reminder of TB meningitis for countries where TB is uncommon. The importance of considering TB in any child with abnormal neurology and of taking prompt family histories to identify children at risk is highlighted.

Indexed as

Tuberculosis, MeningealChildHumansInfantMagnetic Resonance ImagingMaleNeuroimagingSeizuresUnited Kingdomepilepsy and seizuresmeningitispaediatric intensive careTB and other respiratory infections

Identifiers

PMID34413037
PMCPMC8378383
OpenAlexW3196012370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.