Evidence map›Paper›PMID 34412934›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2022

Increased Levels of Circulating Cell-Free mtDNA in the Plasma of Subjects With Late-Life Depression and Frailty: A Preliminary Study.

Emi Ampo, Ana Paula Mendes-Silva, Vanessa Goncalves, Jenna M Bartley, George A Kuchel, Breno S Diniz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  9. Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Emi AmpoOregon State University (EA), Corvallis, OR, USA.
Ana Paula Mendes-SilvaCampbell Family Mental Health Research Institute (APMS, VG, BSD), Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Vanessa GoncalvesCampbell Family Mental Health Research Institute (APMS, VG, BSD), Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Jenna M BartleyUConn Center on Aging, University of Connecticut Health Center (JMB, GAK, BSD), Farmington, CT, USA.
George A KuchelUConn Center on Aging, University of Connecticut Health Center (JMB, GAK, BSD), Farmington, CT, USA.
Breno S DinizCampbell Family Mental Health Research Institute (APMS, VG, BSD), Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; UConn Center on Aging, University of Connecticut Health Center (JMB, GAK, BSD), Farmington, CT, USA; Department of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA. Electronic address: diniz@uchc.edu.
Centre for Addiction and Mental Health · CAUConn Health · USOregon State University · US

Funding

THE SENDEP STUDY: LINKING MOLECULAR SENESCENCE CHANGES TO DEPRESSION AND COGNITIVE IMPAIRMENT IN LATE LIFER01MH115953 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DINIZ, BRENO SATLER · 2019 to 2023
$3.0M
NIMH NIH HHS R01 MH115953
6 · The paper itself

Abstract

objectiveTo evaluate the circulating cell-free mitochondrial DNA (ccf-mtDNA) levels, a marker of cellular stress and damage, in older adults with late-life depression (LLD) and frailty. We hypothesize that individuals with both frailty and LLD will have higher ccf-mtDNA levels than individuals with either condition in isolation.

methodsFifty-three older adults (Never Depressed+Robust (reference group, n = 16), LLD+Robust (n = 9), Never Depressed+Prefrail/Frail (n = 5), and LLD+Prefrail/Frail (n = 23)) were included in the study. DNA was extracted from EDTA plasma samples, and ccf-mtDNA was quantified by RT-PCR.

resultsWe found a statistically significant difference in the levels of ccf-mtDNA across groups (F

conclusionThe coexistence of LLD and frailty is associated with increased markers of cellular damage and stress (i.e., ccf-mtDNA). Our results suggest that these conditions may share cellular stress and mitochondrial dysfunction phenomena as a common biological mechanism, offering potential future opportunities for geroscience-guided interventions for these conditions.

Indexed as

Cell-Free Nucleic AcidsFrailtyAgedDepressionDNA, MitochondrialHumansMitochondriaCell-Free Nucleic AcidsDNA, Mitochondrialagingcellular stresscirculating cell-free mitochondrial DNAfrailtyLate-life depressionmitochondria dysfunction

Identifiers

PMID34412934
PMCPMC8799751
OpenAlexW3190680223

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.