Evidence map›Paper›PMID 34412924›Full record

ReviewTrends in biotechnology2022

Regenerating dynamic organs using biomimetic patches.

Parth Chansoria, Emma L Etter, Juliane Nguyen

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  18. Nanocarrier-hydrogel composite delivery systems for precision drug release.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Parth ChansoriaDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Emma L EtterDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Juliane NguyenDivision of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: julianen@email.unc.edu.

Funding

Polarizing Macrophages to Tumor Suppressors by Blocking Multiple CCR2 Chemokine Receptor EpitopesR01CA241679 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NGUYEN, JULIANE · 2020 to 2024
$1.9M
RNA EXO-Codes: A novel way to reprogram pathological exosomesR01EB023262 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NGUYEN, JULIANE · 2017 to 2020
$1.7M
Antibody Fragments as Biochemical Tools to Interrogate CD9 Function in Inflammatory DiseasesR21GM135853 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NGUYEN, JULIANE, WOHLFERT, ELIZABETH · 2020 to 2021
$433k
NCI NIH HHS R01 CA241679NIBIB NIH HHS R01 EB023262NIGMS NIH HHS R21 GM135853
6 · The paper itself

Abstract

The regeneration of dynamic organs remains challenging because they are intrinsically anisotropic and undergo large volumetric deformation during normal or pathological function. This hampers the durability and applicability of regenerative medicine approaches. To address the challenges of organ dynamics, a new class of patches have emerged with anisotropic and auxetic properties that mimic native tissue biomechanics and accommodate volumetric deformation. Here, we outline the critical design, materials, and processing considerations for achieving optimal patch biomechanics according to target pathology and summarize recent advances in biomimetic patches for dynamic organ regeneration. Furthermore, we discuss the challenges and opportunities which, if overcome, would open up new applications in organ regeneration and expedite the clinical translation of patch-based therapeutics.

Indexed as

BiomimeticsTissue EngineeringRegenerationRegenerative Medicineanisotropicauxeticnegative Poisson’s ratiopatchregenerationtissue engineering

Identifiers

PMID34412924
PMCPMC8831394

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.