ArticleStroke2021
Serum Zinc Levels and Incidence of Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study.
Article in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Sex-Specific Prospective Association of Serum Zinc Concentration with Cardiovascular Disease and Mortality: A 10-Year Population-Based Cohort Study.Journal of cardiovascular translational research · 2026Article
- Trace elements and risk of diabetes-related vascular complications: results from the EPIC-Potsdam cohort study.Cardiovascular diabetology · 2025Article
- Zinc deficiency and risk of intracerebral hemorrhage: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Cerebrovascular accidents association between serum trace elements and toxic metals level, a case-control study.PloS one · 2025Article
- Heavy metal pollution and ischemic stroke: multimechanistic pathogenesis and countermeasures.Frontiers in public health · 2025Review
- Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke.Life (Basel, Switzerland) · 2024Article
- Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study.European journal of medical research · 2024Article
- Machine learning approaches to identify the link between heavy metal exposure and ischemic stroke using the US NHANES data from 2003 to 2018.Frontiers in public health · 2024Article
- Cumulative Exposure to Oxidized Low-density Lipoprotein is a Potential Predictor for Prognosis in Acute Ischemic Stroke: A Cohort Study.Current pharmaceutical design · 2024Article
- Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39.CNS neuroscience & therapeutics · 2023Review
- Sex differences in depression: An immunological perspective.Brain research bulletin · 2023Review
- The Important Role of Zinc in Neurological Diseases.Biomolecules · 2022Review
- Investigating the Role of Zinc in Atherosclerosis: A Review.Biomolecules · 2022Review
- Diet-Derived Circulating Antioxidants and Risk of Stroke: A Mendelian Randomization Study.Oxidative medicine and cellular longevity · 2022Article
- Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
background and purposeDespite zinc's role as an antioxidant and anti-inflammatory agent, prospective studies relating zinc levels to ischemic stroke risk are lacking. To examine the association between serum zinc levels and incidence of ischemic stroke in a US population.
methodsUsing a case-cohort study nested within the Reasons for Geographic and Racial Differences in Stroke cohort, participants were randomly selected from the Reasons for Geographic and Racial Differences in Stroke cohort to generate a sub-cohort (n=2346). All incident ischemic stroke cases as of September 2012 (n=660) were included, with 62 incident cases overlapping in the sub-cohort. Serum zinc levels were measured at baseline. Barlow-weighted Cox's proportional hazards regression models were used to calculate multivariable-adjusted hazard ratios and the corresponding 95% CI of ischemic stroke by serum zinc levels.
resultsThe median zinc level for the sub-cohort was 121.19 µg/dL (interquartile range, 104.86-140.39 µg/dL). Serum zinc levels were inversely associated with incidence of ischemic stroke after adjustment for potential confounders (quartile 4 versus quartile 1: hazard ratio, 0.78 [95% CI, 0.61-0.98],
conclusionsSerum zinc concentration was inversely associated with incidence of ischemic stroke, especially among women, indicating that low zinc levels may be a risk factor for ischemic stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.