Evidence map›Paper›PMID 34411625›Full record

ArticleBrazilian journal of anesthesiology (Elsevier)

The effects of dexketoprofen on renal ischemia-reperfusion injury: an experimental study.

Ersin Koksal, Yasemin Burcu Ustun, Sezgin Bilgin, Abdurrahman Aksoy, Yavuz Kursad Das, Murat Yarim, Fatih Ozkan, Cengiz Kaya, Burhan Dost

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ersin KoksalOndokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey. Electronic address: ersin.koksal@omu.edu.tr.
Yasemin Burcu UstunOndokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
Sezgin BilginOndokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
Abdurrahman AksoyOndokuz Mayis University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Samsun, Turkey.
Yavuz Kursad DasOndokuz Mayis University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Samsun, Turkey.
Murat YarimOndokuz Mayis University, Faculty of Veterinary Medicine, Department of Pathology, Samsun, Turkey.
Fatih OzkanOndokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
Cengiz KayaOndokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
Burhan DostOndokuz Mayis University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Samsun, Turkey.
Ondokuz Mayıs University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIschemia/reperfusion (I/R) may cause irreversible damage to tissues and organs. We evaluated the effects of dexketoprofen on a renal I/R model in rats.

methodsThe study included 30 male rats. Control group received 1 mL of saline. Dexketoprofen group received 1 mL (25 mg) of dexketoprofen intraperitoneally. After 60 minutes renal ischemia, 23 hours reperfusion was applied. In Sham group, laparotomy was performed with a medial line incision without any additional procedure. Changes in the plasma malondialdehyde (MDA), renal tissue MDA, plasma glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), BUN, creatinine and albumin levels, and histopathological changes were evaluated.

resultsCAT values were significantly lower in Control as compared with the Sham group. Plasma levels of MDA in the Control group were significantly higher than in the Dexketoprofen group. BUN and creatinine values were significantly higher in the Dexketoprofen group. The severity of tissue injury in the Dexketoprofen group was significantly higher than in Control and Sham groups

conclusionAlthough dexketoprofen reduces the I/R-induced systemic inflammation, it increases renal tissue damage.

Indexed as

Reperfusion InjuryAnimalsCreatinineHumansKetoprofenKidneyMaleMalondialdehydeRatsRats, WistarTromethamineCreatininedexketoprofen trometamolKetoprofenMalondialdehydeTromethamineDexketoprofenIschemia- reperfusionKidneyMalondialdehydeReactive oxygen species

Identifiers

PMID34411625
PMCPMC9373263
OpenAlexW3193932807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.