Evidence map›Paper›PMID 34411593›Full record

ArticleDevelopmental biology2021

Proliferation in the developing intestine is regulated by the endosomal protein Endotubin.

Meng-Han Wu, Marco Padilla-Rodriguez, Isabella Blum, Abigail Camenisch, Vanessa Figliuolo da Paz, Matthew Ollerton, John Muller, Samina Momtaz, Stefanie A T Mitchell, Pawel Kiela and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Meng-Han WuDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: meng.wu@cuanschutz.edu.
Marco Padilla-RodriguezDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: marco@arizona.edu.
Isabella BlumDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: blumisabella@email.arizona.edu.
Abigail CamenischDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: abigail.camenisch@cuanschutz.edu.
Vanessa Figliuolo da PazDepartments of Pediatrics and Immunobiology, University of Arizona, Tucson, AZ, USA. Electronic address: vanessafigliuolo@yahoo.com.br.
Matthew OllertonDepartment of Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: matthewollerton@arizona.edu.
John MullerDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: jmuller@macalaster.edu.
Samina MomtazDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: saminamomtaz@email.arizona.edu.
Stefanie A T MitchellDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: satmitchell@arizona.edu.
Pawel KielaDepartments of Pediatrics and Immunobiology, University of Arizona, Tucson, AZ, USA; Steele Children's Research Center, University of Arizona, Tucson, AZ, USA. Electronic address: pkiela@arizona.edu.
Curtis ThorneDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA; Bio5 Institute, University of Arizona, Tucson, AZ, USA; Steele Children's Research Center, University of Arizona, Tucson, AZ, USA. Electronic address: curtisthorne@arizona.edu.
Jean M WilsonDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA; Bio5 Institute, University of Arizona, Tucson, AZ, USA. Electronic address: jeanw@arizona.edu.
Christopher M CoxDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: coxc@email.arizona.edu.
University of Arizona · US

Funding

Endocytic Regulation of Intestinal DevelopmentR01DK109701 · NIDDK · UNIVERSITY OF ARIZONA · PI WILSON, JEAN M · 2017 to 2021
$2.1M
Research Supplements to Promote Diversity in Health-Related ResearchR01DK119198 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI GAO, NAN, KIELA, PAWEL R · 2019 to 2023
$1.9M
Modulation of dendritic cell function in the pathogenesis of Inflammatory Bowel DiseasesR01DK109711 · NIDDK · UNIVERSITY OF ARIZONA · PI GHISHAN, FAYEZ KHALAF, KIELA, PAWEL R · 2016 to 2020
$1.7M
The role of kinase signaling in intestinal epithelial homeostasisR00DK103126 · NIDDK · UNIVERSITY OF ARIZONA · PI THORNE, CURTIS ANDREW · 2018 to 2020
$747k
NIDDK NIH HHS R00 DK103126NIDDK NIH HHS R01 DK109701NIDDK NIH HHS R01 DK109711NIDDK NIH HHS R01 DK119198
6 · The paper itself

Abstract

During postnatal intestinal development, the intestinal epithelium is highly proliferative, and this proliferation is regulated by signaling in the intervillous and crypt regions. This signaling is primarily mediated by Wnt, and requires membrane trafficking. However, the mechanisms by which membrane trafficking regulates signaling during this developmental phase are largely unknown. Endotubin (EDTB, MAMDC4) is an endosomal protein that is highly expressed in the apical endocytic complex (AEC) of villus enterocytes during fetal and postnatal development, and knockout of EDTB results in defective formation of the AEC and giant lysosome. Further, knockout of EDTB in cell lines results in decreased proliferation. However, the role of EDTB in proliferation during the development of the intestine is unknown. Using Villin-CreERT2 in EDTB

Indexed as

AnimalsCell DifferentiationCell ProliferationEndosomesEnterocytesFemaleGlycoproteinsIntestinal MucosaIntestinesMaleMiceMice, KnockoutMicrofilament ProteinsWnt ProteinsWnt Signaling PathwayGlycoproteinsMAMDC4 protein, humanMicrofilament ProteinsvillinWnt ProteinsEndotubinIntestinal proliferationMAMDC4TraffickingWnt

Identifiers

PMID34411593
PMCPMC8555764
OpenAlexW3195473151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.