Evidence map›Paper›PMID 34411574›Full record

ArticleBiophysical journal2021

Gating current noise produced by Brownian models of a voltage sensor.

Luigi Catacuzzeno, Fabio Franciolini, Francisco Bezanilla, Robert S Eisenberg

Abstract read
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. HInternational journal of molecular sciences · 2025
    Review
  2. Fifty years of gating currents and channel gating.The Journal of general physiology · 2023
    Review
  3. Article
  4. Setting Boundaries for Statistical Mechanics.Molecules (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luigi CatacuzzenoDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy. Electronic address: luigi.catacuzzeno@unipg.it.
Fabio FrancioliniDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
Francisco BezanillaDepartment of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Sciences, Chicago, Illinois.
Robert S EisenbergDepartment of Physiology and Biophysics, Rush University, Chicago, Illinois; Department of Applied Mathematics, Illinois Institute of Technology, Chicago, Illinois.

Funding

The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
NIGMS NIH HHS R01 GM030376
6 · The paper itself

Abstract

The activation of voltage-dependent ion channels is associated with the movement of gating charges, which give rise to gating currents. Although gating currents from a single channel are too small to be detected, analysis of the fluctuations of macroscopic gating currents from a population of channels allows a good guess of their magnitude. The analysis of experimental gating current fluctuations, when interpreted in terms of a rate model of channel activation and assuming sufficiently high bandwidth, is in accordance with the presence of a main step along the activation pathway carrying a charge of 2.3-2.4 e

Indexed as

Ion Channel GatingIon ChannelsIon Channels

Identifiers

PMID34411574
PMCPMC8510977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.