Evidence map›Paper›PMID 34411324›Full record

ArticleMagnetic resonance in medicine2022

In vivo spectral editing of phosphorylethanolamine.

Steve C N Hui, Helge J Zöllner, Georg Oeltzschner, Richard A E Edden, Muhammad G Saleh

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Comprehensive Speciation and Computational Study of CuMolecules (Basel, Switzerland) · 2025
    Article
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  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Steve C N HuiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1523-4040
Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7148-292X
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Muhammad G SalehDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6921-112X

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
State of the Art 3T Research ScannerS10OD021648 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2016 to 2016
$2.0M
Neurometabolic profile of tobacco smoking in HIV-infected IndividualsR00DA051315 · NIDA · CHILDREN'S HOSP OF PHILADELPHIA · PI SALEH, MUHAMMAD · 2023 to 2025
$747k
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
Neurometabolic profile of tobacco smoking in HIV-infected IndividualsK99DA051315 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI SALEH, MUHAMMAD G · 2021 to 2022
$347k
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.K99AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2019 to 2020
$171k
NIA NIH HHS K99 AG062230NIA NIH HHS R00 AG062230NIBIB NIH HHS P41 EB015909NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIDA NIH HHS K99 DA051315NIDA NIH HHS R00 DA051315NIH HHS S10 OD021648
6 · The paper itself

Abstract

purposeTo demonstrate J-difference editing of phosphorylethanolamine (PE) with chemical shifts at 3.22 (PE

methodsDensity-matrix simulations of MEGA-PRESS (Mescher-Garwood PRESS) for PE were performed at TEs ranging from 80 to 200 ms in steps of 2 ms, applying 20-ms editing pulses (ON/OFF) at (1) 3.98/7.5 ppm to detect PE

resultsSimulations show substantial TE modulation of the intensity and shape of the edited signals due to coupling evolution. Simulated and phantom integrals suggest that TEs of 110 ms and 90 ms were optimal for the edited detection of PE

conclusionSimulations and in vivo MEGA-PRESS of PE demonstrate that both PE

Indexed as

Magnetic Resonance ImagingComputer SimulationEthanolaminesHumansPhantoms, ImagingEthanolaminesphosphorylethanolaminemagnetic resonance spectroscopyMagnetic resonance spectroscopyMEGA-PRESSphosphorylethanolaminespectral editingspectral editing phosphorylethanolamine.

Identifiers

PMID34411324
PMCPMC8616810

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.