Evidence map›Paper›PMID 34411308›Full record

ArticlePhotochemistry and photobiology2022

Light-responsive and Protic Ruthenium Compounds Bearing Bathophenanthroline and Dihydroxybipyridine Ligands Achieve Nanomolar Toxicity towards Breast Cancer Cells.

Olaitan E Oladipupo, Spenser R Brown, Robert W Lamb, Jessica L Gray, Colin G Cameron, Alexa R DeRegnaucourt, Nicholas A Ward, James Fletcher Hall, Yifei Xu, Courtney M Petersen and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Olaitan E OladipupoDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
Spenser R BrownDepartment of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0002-3665-8133
Robert W LambDepartment of Chemistry, Mississippi State University, Mississippi State, MS, USA.ORCID 0000-0001-6463-3809
Jessica L GrayDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
Colin G CameronDepartment of Chemistry and Biochemistry, University of Texas Arlington, Arlington, TX, USA.
Alexa R DeRegnaucourtDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
Nicholas A WardDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
James Fletcher HallDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
Yifei XuDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0002-0379-7188
Courtney M PetersenDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
Fengrui QuDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
Ambar B ShresthaDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.
Matthew K ThompsonDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0002-1964-3896
Marco BonizzoniDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0003-0155-5481
Charles Edwin WebsterDepartment of Chemistry, Mississippi State University, Mississippi State, MS, USA.ORCID 0000-0002-6917-2957
Sherri A McFarlandDepartment of Chemistry and Biochemistry, University of Texas Arlington, Arlington, TX, USA.ORCID 0000-0002-8028-5055
Yonghyun KimDepartment of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0001-6344-1258
Elizabeth T PapishDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0002-7937-8019
University of Alabama · USThe University of Texas at Arlington · USMississippi State University · USOak Ridge Associated Universities · US

Funding

Immunomodulating Ruthenium Metal Complexes for Melanoma PhotodynamicTherapyR01CA222227 · NCI · UNIVERSITY OF TEXAS ARLINGTON · PI GUJAR, SHASHI, MCFARLAND, SHERRI · 2018 to 2022
$2.6M
Singlet oxygen formation vs. photodissociation for protic ruthenium anticancer compounds: The oxygenated substituent determines the mode of action and the cytotoxicityR15GM132803 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI PAPISH, ELIZABETH TABITHA · 2019 to 2022
$844k
NCI NIH HHS R01 CA222227NIGMS NIH HHS R15 GM132803
6 · The paper itself

Abstract

We report new ruthenium complexes bearing the lipophilic bathophenanthroline (BPhen) ligand and dihydroxybipyridine (dhbp) ligands which differ in the placement of the OH groups ([(BPhen)

Indexed as

Breast NeoplasmsRutheniumFemaleHumansLigandsPhenanthrolinesRuthenium CompoundsbathophenanthrolineLigandsPhenanthrolinesRutheniumRuthenium Compounds

Identifiers

PMID34411308
PMCPMC8810589
OpenAlexW3193848576

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.