Evidence map›Paper›PMID 34411281›Full record

ArticleBritish journal of pharmacology2021

The feeding behaviour of Amyotrophic Lateral Sclerosis mouse models is modulated by the Ca

Germana Cocozza, Stefano Garofalo, Marta Morotti, Giuseppina Chece, Alfonso Grimaldi, Mario Lecce, Ferdinando Scavizzi, Rossella Menghini, Viviana Casagrande, Massimo Federici and 3 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Germana CocozzaInstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, Pozzilli, Italy.ORCID 0000-0001-7005-7983
Stefano GarofaloDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Marta MorottiDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Giuseppina CheceDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Alfonso GrimaldiCenter for Life Nanoscience, Istituto Italiano di Tecnologia@Sapienza, Rome, Italy.
Mario LecceDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Ferdinando ScavizziEMMA CNR, Monterotondo, Italy.
Rossella MenghiniDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Viviana CasagrandeDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Massimo FedericiDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Marcello RaspaEMMA CNR, Monterotondo, Italy.
Heike WulffDepartment of Pharmacology, University of California, Davis, Davis, California, USA.ORCID 0000-0003-4437-5763
Cristina LimatolaInstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, Pozzilli, Italy.
Sapienza University of Rome · ITUniversity of Rome Tor Vergata · ITEuropean Molecular Biology Laboratory · ITIstituto Neurologico Mediterraneo · ITItalian Institute of Technology · ITUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAmyotrophic lateral sclerosis (ALS) patients exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution of neuroinflammation to deregulations of feeding behaviour in ALS has not been studied in detail. We here investigated if microglial K EXPERIMENTAL APPROACH: hSOD1 KEY

resultsWe found that treatment of hSOD1 CONCLUSION AND IMPLICATIONS: Using ALS mouse models, we describe defects in the hypothalamic melanocortin system that affect appetite control. These results reveal a new regulatory role for K

Indexed as

Amyotrophic Lateral SclerosisFeeding BehaviorAnimalsDisease Models, AnimalEnergy MetabolismHomeostasisMelanocortinsMiceMice, TransgenicMicrogliaPotassium Channels, Calcium-ActivatedPyrazolesReceptors, CannabinoidSpinal CordSuperoxide Dismutase-1Weight GainMelanocortinsPotassium Channels, Calcium-ActivatedPyrazolesReceptors, CannabinoidSuperoxide Dismutase-1TRAM 34CSFhypothalamus feeding behaviourion channelsmicroglianeurodegenerative diseaseneuroinflammation

Identifiers

PMID34411281
PMCPMC9293222
OpenAlexW3194018201

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.