ArticleAging2021
COVID-19 mortality rate in children is U-shaped.
Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- MIS-C: Diagnosis, Management, and Outcomes.Open forum infectious diseases · 2026Review
- Bacterial Infections, Trends, and Resistance Patterns in the Time of the COVID-19 Pandemic in Romania-A Systematic Review.Antibiotics (Basel, Switzerland) · 2024Review
- Article
- The mechanisms of milder clinical symptoms of COVID-19 in children compared to adults.Italian journal of pediatrics · 2024Review
- Review
- Impact of COVID-19 on Spanish mortality rates in 2020 by age and sex.Journal of public health (Oxford, England) · 2023Article
- Considerations for vaccinating children against COVID-19.BMJ paediatrics open · 2023Review
- COVID-19 deaths in children and young people in England, March 2020 to December 2021: An active prospective national surveillance study.PLoS medicine · 2022Article
- Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity.BMJ paediatrics open · 2022Article
- Survival analysis and mortality predictors of COVID-19 in a pediatric cohort in Mexico.Frontiers in public health · 2022Article
- Comparison of the Clinical and Laboratory Features of COVID and Influenza in Children.Mediterranean journal of hematology and infectious diseases · 2022Review
- Progress in the Diagnosis and Treatment of COVID-19 in Children: A Review.International journal of general medicine · 2021Review
- Considerations for the Safe Operation of Schools During the Coronavirus Pandemic.Frontiers in public health · 2021Review
- COVID-19 mortality in the Philippines: province-level ecological analysis, 2020-2023.Western Pacific surveillance and response journal : WPSARArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Children are known to be better protected from COVID-19 than adults, but their susceptibility patterns and the risk relative to other diseases are insufficiently defined. Here, we found that the COVID-19 mortality rate is U-shaped in childhood: it initially decreases, reaching the minimum at the ages 3-10 years, and then increases throughout life. All-cause mortality and mortality from other diseases, such as pneumonia and influenza, show a similar pattern; however, childhood mortality rates from COVID-19 are considerably lower than from other diseases, with the best relative protection achieved at the youngest ages. Consistent with this, the fraction of COVID-19 deaths among all deaths increases as a function of age throughout childhood and the entire life. We discuss implications of the elevated postnatal COVID-19 risk and lower childhood COVID-19 mortality compared to other diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.