Evidence map›Paper›PMID 34410700›Full record

ArticleACS sensors2021

Toward Rapid Detection of Viable Bacteria in Whole Blood for Early Sepsis Diagnostics and Susceptibility Testing.

Sharath Narayana Iyengar, Jiri Dietvorst, Amparo Ferrer-Vilanova, Gonzalo Guirado, Xavier Muñoz-Berbel, Aman Russom

Open access · hybridAbstract read
In one paragraph

Article in ACS sensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. mNGS-Supported Interpretation ofInfection and drug resistance · 2026
    Article
  4. Validation of CRownLab Pneumoplex for the Detection ofInternational journal of microbiology · 2026
    Article
  5. Article
  6. Article
  7. Isolation and detection of target cells in bloodAnalytical methods : advancing methods and applications · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Diagnostics (Basel, Switzerland) · 2024
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sharath Narayana IyengarDivision of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm 17165, Sweden.ORCID 0000-0001-5348-3526
Jiri DietvorstInstituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Universitat Autónoma de Barcelona, Cerdanyola del vallès, Barcelona 08193, Spain.
Amparo Ferrer-VilanovaInstituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Universitat Autónoma de Barcelona, Cerdanyola del vallès, Barcelona 08193, Spain.ORCID 0000-0002-4223-8442
Gonzalo GuiradoDepartment de Química, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona 08193, Spain.
Xavier Muñoz-BerbelInstituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Universitat Autónoma de Barcelona, Cerdanyola del vallès, Barcelona 08193, Spain.ORCID 0000-0002-6447-5756
Aman RussomDivision of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm 17165, Sweden.
Universitat Autònoma de Barcelona · ESScience for Life Laboratory · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a serious bloodstream infection where the immunity of the host body is compromised, leading to organ failure and death of the patient. In early sepsis, the concentration of bacteria is very low and the time of diagnosis is very critical since mortality increases exponentially with every hour after infection. Common culture-based methods fail in fast bacteria determination, while recent rapid diagnostic methods are expensive and prone to false positives. In this work, we present a sepsis kit for fast detection of bacteria in whole blood, here achieved by combining selective cell lysis and a sensitive colorimetric approach detecting as low as 10

Indexed as

Ferric CompoundsSepsisBacteriaHumansFerric CompoundsbacteriabloodcolorimetricE. coliPrussian blueselective cell lysissepsis

Identifiers

PMID34410700
PMCPMC8477386
OpenAlexW3195394936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.