Assessing the Relationship Between Nitrate-Reducing Capacity of the Oral Microbiome and Systemic Outcomes.

Charlene E Goh, Bruno Bohn, Ryan T Demmer

Open access · greenAbstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

2.7field-weighted citation impact, top 13% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Charlene E GohFaculty of Dentistry, National University of Singapore, Singapore, Singapore. dengec@nus.edu.sg.

Bruno BohnDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Ryan T DemmerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Columbia University · USNational University of Singapore · SGUniversity of Minnesota · US

Funding

The Subgingival Microbiome and Impaired Glucose RegulationR01DK102932 · NIDDK · UNIVERSITY OF MINNESOTA · PI DEMMER, RYAN T. · 2015 to 2019

$3.1M

NIDDK NIH HHS R01 DK102932

6 · The paper itself

Abstract

The significance of the oral microbiome in the generation of the nitric oxide (NO) via the enterosalivary nitrate-nitrite-nitric oxide pathway is increasingly recognized, directly linking the oral microbiome to cardiometabolic outcomes influenced by NO. The objective of this chapter is to outline a strategy of identifying pathway-specific bacterial taxa or predicted genes of interest from 16S rRNA data, specifically in the enterosalivary pathway of nitrate reduction, and analyzing their relationship with cardiometabolic outcomes using multivariable regression models.

Indexed as

MicrobiotaCardiovascular DiseasesHumansMouthNitratesNitric OxideNitritesRNA, Ribosomal, 16SNitratesNitric OxideNitritesRNA, Ribosomal, 16SNitrate, Nitrite, Nitric oxide pathwayOral microbiomePathway activity prediction

Identifiers

PMID34410644

DOI10.1007/978-1-0716-1518-8_9

PMCPMC9277710

OpenAlexW3195593562

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.