Evidence map›Paper›PMID 34410624›Full record

ArticleGenes & genomics2021

RRV-induced biliary atresia in neonatal mice involves CD8 + T lymphocyte killer cells and the Notch signaling pathway.

Xinmin Si, Ji Chen, Lei Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Immunology of Biliary Atresia.Seminars in pediatric surgery · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xinmin Si *Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No.300 of Guangzhou Road, Nanjing, 210029, China.
Ji Chen *Department of General Surgery, Children's Hospital of Nanjing Medical University, No.72 of Guangzhou Road, Nanjing, 210008, China.
Lei HuangDepartment of General Surgery, Children's Hospital of Nanjing Medical University, No.72 of Guangzhou Road, Nanjing, 210008, China. surgeonhuang@126.com.ORCID 0000-0002-3975-9546
Nanjing Children's Hospital · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersistent inflammation induced by viral infection may contribute to the pathogenesis of biliary atresia (BA). Moreover, CD4

objectiveThus, we aimed to explore the dynamics of inflammatory cell infiltration and inflammation-regulated pathways in liver-specific inflammatory responses.

methodsNeonatal Balb/C mice were intraperitoneally infected with 1 × 10

resultsThe numbers of CD4

conclusionThe DAPT-based intervention could reduce expression of CD8

Indexed as

Signal TransductionAnimalsAnimals, NewbornBiliary AtresiaCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChlorocebus aethiopsDisease Models, AnimalKiller Cells, NaturalLiverMiceMice, Inbred BALB CRotavirusSpleenAnimal modelBiliary atresiaCD8 TcNeonatal miceNotch signaling pathway

Identifiers

PMID34410624
OpenAlexW3194345455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.