ArticleIndian journal of pediatrics2022
Physical Growth and Its Determinants in Indian Children with Down Syndrome, from 3 Months to 5 Years of Age.
Article in Indian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Head circumference percentiles in Indian children with Down syndrome.Frontiers in pediatrics · 2025Article
- Prospective Observational Study of Sympathetic Failure as a Mechanism Associated with Bradycardia During Induction of General Anesthesia in Children with Down Syndrome.The journal of pediatric research · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
objectiveTo compare the growth of Indian children with Down syndrome (DS), with typically developing Indian children. The effect of comorbidities on their physical growth was also evaluated, so that factors affecting growth can be identified early and timely interventions be planned.
methodsA cross-sectional study was conducted at the All India Institute of Medical Sciences, New Delhi from June 2015 to June 2017. Children with karyotype-proven DS within age group of 3 mo to 5 y were enrolled as study subjects. Children with DS having mosaic karyotype were excluded. Anthropometry and associated comorbidities were assessed.
resultsHundred and eight children with DS were enrolled, mean WHO z scores were-WAZ: -2.31 (SD 1.44), HAZ: -2.51 (SD 1.47), BAZ: -1.07 (SD 1.8), and HCZ: -2.79 (SD 1.21). Congenital heart disease (in 44.5% children), hypothyroidism (in 27.7%), and anemia (in 50%) were the common comorbidities. Growth parameters of children with and without any comorbidity were significantly different, mean WHO z scores were WAZ -2.61 vs. -1.09 (p = 0.005), HAZ -2.43 vs. -2.41 (p = 0.3), BAZ -1.49 vs. -0.38 (p = 0.001), and HCZ -3.13 vs. -2.33 (p = 0.001).
conclusionGrowth of Indian children with DS is significantly less compared to normally growing children. Weight was affected maximum during infancy, length was more affected as the age progressed, head circumference was affected similarly in all age groups, whereas BMI showed almost progressive increase with age. Children with severe heart disease had significantly lower BMI whereas children with treated hypothyroidism had better growth. There is a need for a large longitudinal study on Indian children with DS to construct Indian DS-specific growth charts.
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