Evidence map›Paper›PMID 34410604›Full record

ArticleMolecular neurobiology2021

Cerebellar Long Noncoding RNA Expression Profile in a Niemann-Pick C Disease Mouse Model.

Shiqian Han, Meng Ren, Tianyin Kuang, Mao Pang, Dongwei Guan, Yesong Liu, Yong Wang, Wengeng Zhang, Zhijia Ye

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Severe neurometabolic phenotype inFrontiers in molecular neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Shiqian HanDepartment of Tropical Medicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Meng RenLaboratory Animal Research Center, Chongqing University School of Medicine, Chongqing, 400044, China.
Tianyin KuangLaboratory Animal Research Center, Chongqing University School of Medicine, Chongqing, 400044, China.
Mao PangLaboratory Animal Research Center, Chongqing University School of Medicine, Chongqing, 400044, China.
Dongwei GuanLaboratory Animal Research Center, Chongqing University School of Medicine, Chongqing, 400044, China.
Yesong LiuCornell University, Ithaca, NY, 14853, USA.
Yong WangDepartment of Laboratory Animal Science, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Wengeng ZhangPrecision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhijia YeDepartment of Tropical Medicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, China. yezj918@cqu.edu.cn.ORCID http://orcid.org/0000-0002-7926-7159
Chongqing University · CNArmy Medical University · CNCornell University · USSichuan University · CN

Funding

National Natural Science Foundation of China 81170471the Emphasis Basic Medical Scientific Research Project Fund of China AWS17J007
6 · The paper itself

Abstract

Niemann-Pick type C (NP-C) disease is a neurodegenerative lysosomal storage disorder primarily caused by mutations in NPC1. However, its pathogenesis remains poorly understood. While mounting evidence has demonstrated the involvement of long noncoding RNAs (lncRNAs) in the pathogenesis of neurodegenerative disorders, the lncRNA expression profile in NP-C has not been determined. Here, we used RNA-seq analysis to determine lncRNA and mRNA expression profiles of the cerebella of NPC1

Indexed as

AnimalsBase SequenceCerebellumDisease Models, AnimalGait AtaxiaGene Expression ProfilingGene OntologyGene Regulatory NetworksLipopolysaccharidesMiceMice, Inbred BALB CMice, KnockoutNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CReal-Time Polymerase Chain ReactionRNA InterferenceH19 long non-coding RNALipopolysaccharidesNiemann-Pick C1 ProteinNpc1 protein, mouseRNA, Long NoncodingRNA, MessengerRNA, Small InterferingCerebellumCoexpression networkLncRNA H19Long noncoding RNAsNiemann-Pick type C disease

Identifiers

PMID34410604
PMCPMC8599378
OpenAlexW3196090560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.