Evidence map›Paper›PMID 34410576›Full record

ReviewJournal of neuro-oncology2022

Focused ultrasound: growth potential and future directions in neurosurgery.

Michael Zhang, Adrian Rodrigues, Quan Zhou, Gordon Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Michael ZhangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA. zhangm@stanford.edu.ORCID http://orcid.org/0000-0002-7067-0689
Adrian RodriguesDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Quan ZhouDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Gordon LiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · USStanford Medicine · US

Funding

STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAMT32CA009695 · NCI · STANFORD UNIVERSITY · PI BRUCE L DANIEL, Jeremy Dahl · 1993 to 2026
$7.7M
Optical Imaging to Improve Surgery & Targeted Therapy in Brain TumorsR01CA239257 · NCI · STANFORD UNIVERSITY · PI LI, GORDON, ROSENTHAL, EBEN L. · 2019 to 2023
$2.9M
Prototype optical device for image guided surgery with panitumumab-IRDye800R01CA190306 · NCI · STANFORD UNIVERSITY · PI ROSENTHAL, EBEN L. · 2015 to 2019
$2.6M
NCI NIH HHS R01 CA190306NIH HHS 5T32CA009695-27
6 · The paper itself

Abstract

Over the past two decades, vast improvements in focused ultrasound (FUS) technology have made the therapy an exciting addition to the neurosurgical armamentarium. In this time period, FUS has gained US Food and Drug Administration (FDA) approval for the treatment of two neurological disorders, and ongoing efforts seek to expand the lesion profile that is amenable to ultrasonic intervention. In the following review, we highlight future applications for FUS therapy and compare its potential role against established technologies, including deep brain stimulation and stereotactic radiosurgery. Particular attention is paid to tissue ablation, blood-brain-barrier opening, and gene therapy. We also address technical and infrastructural challenges involved with FUS use and summarize the hurdles that must be overcome before FUS becomes widely accepted in the neurosurgical community.

Indexed as

Nervous System DiseasesUltrasonic TherapyForecastingHumansNeurosurgeryBlood brain barrier openingCost-effectivenessFocused ultrasoundGene therapyThermoablation

Identifiers

PMID34410576
OpenAlexW3194700499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.