ArticleAnnals of intensive care2021
Case fatality inequalities of critically ill COVID-19 patients according to patient-, hospital- and region-related factors: a French nationwide study.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies.Aging clinical and experimental research · 2024Pooled it
- Trial
- Validation of algorithms for identifying people living with HIV in French medico-administrative databases: implications for HIV surveillance.BMC medical research methodology · 2026Article
- Revisiting the link between COVID-19 incidence and infection fatality rate during the first pandemic wave.Scientific reports · 2025Article
- Relationship between multimorbidity, SARS-COV-2 infection and long COVID: a cross-sectional population-based French survey.BMC medicine · 2025Article
- Herpes simplex encephalitis in France: incidence, 6-month rehospitalizations and mortality.Infection · 2024Article
- Impact of vaccine coverage and disruption to health services on COVID-19 in Ukraine.Scientific reports · 2024Article
- Prognostic value of respiratory compliance course on mortality in COVID-19 patients with vv-ECMO.Annals of intensive care · 2023Article
- Observational
- The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists.Annals of intensive care · 2023Review
- Impact of lockdown on cardiovascular disease hospitalizations in a Zero-COVID-19 country.Public health · 2023Article
- Cognitive Decline Before and During COVID-19 Pandemic Among Older People With Multimorbidity: A Longitudinal Study.Journal of the American Medical Directors Association · 2023Article
- Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study.Critical care (London, England) · 2023Article
- Estimating the burden of influenza-attributable severe acute respiratory infections on the hospital system in Metropolitan France, 2012-2018.BMC infectious diseases · 2023Article
- Performance of French medico-administrative databases in epidemiology of infectious diseases: a scoping review.Frontiers in public health · 2023Article
- Association of burnout and intention-to-leave the profession with work environment: A nationwide cross-sectional study among Belgian intensive care nurses after two years of pandemic.International journal of nursing studies · 2023Article
- Major interregional differences in France of COVID-19 hospitalization and mortality from January to June 2020.Revue d'epidemiologie et de sante publique · 2022Article
- Transition matrices model as a way to better understand and predict intra-hospital pathways of covid-19 patients.Scientific reports · 2022Article
- Outcomes of Patients With Active Cancer and COVID-19 in the Intensive-Care Unit: A Multicenter Ambispective Study.Frontiers in oncology · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe COVID-19 sanitary crisis inflicted different challenges regarding the reorganization of the human and logistic resources, particularly in intensive care unit (ICU). Interdependence between regional pandemic burden and individual outcome remains unknown. The study aimed to assess the association between ICU bed occupancy and case fatality rate of critically ill COVID-19 patients.
methodsA cross-sectional study was performed in France, using the national hospital discharge database from March to May, 2020. All patients admitted to ICU for COVID-19 were included. Case fatality was described according to: (i) patient's characteristics (age, sex, comorbid conditions, ICU interventions); (ii) hospital's characteristics (baseline ICU experience assessed by the number of ICU stays in 2019, number of ICU physicians per bed), and (iii) the regional outbreak-related profiles (workload indicator based on ICU bed occupancy). The determinants of lethal outcome were identified using a logistic regression model.
results14,513 COVID-19 patients were admitted to ICU; 4256 died (29.3%), with important regional inequalities in case fatality (from 17.6 to 33.5%). Older age, multimorbidity and clinical severity were associated with higher mortality, as well as a lower baseline ICU experience of the health structure. Regions with more than 10 days with ≥ 75% of ICU occupancy by COVID-19 patients experienced an excess of mortality (up to adjusted OR = 2.2 [1.9-2.6] for region with the highest occupancy rate of ICU beds).
conclusionsThe regions with the highest burden of care in ICU were associated with up to 2.2-fold increase of death rate.
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