Evidence map›Paper›PMID 34410507›Full record

ArticleAmino acids2021

Anti-inflammatory effect of L-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters.

Khetyma Moreira Fonseca, Dionys Macda RodriguesCosta, Valderlon Freitas da Silva, Jelson Lina de Carvalho, Ana Patrícia Oliveira, Francisca Beatriz de Melo Sousa, André Luis Fernandes Lopes, Conceição da Silva Martins, Letícia de Sousa Chaves, Lucas Antonio Duarte Nicolau and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Anti-inflammatory peptide therapeutics and the role of sulphur containing amino acids (cysteine and methionine) in inflammation suppression: A review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Khetyma Moreira FonsecaLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil.
Dionys Macda RodriguesCostaNucleus of Studies in Microscopy and Image Processing (NEMPI), Federal University of Ceará, St. Delmiro de Farias, sn, Fortaleza, Ceará, CEP 60430-270, Brazil.
Valderlon Freitas da SilvaNucleus of Studies in Microscopy and Image Processing (NEMPI), Federal University of Ceará, St. Delmiro de Farias, sn, Fortaleza, Ceará, CEP 60430-270, Brazil.
Jelson Lina de CarvalhoLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil.
Ana Patrícia OliveiraLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil.
Francisca Beatriz de Melo SousaLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil.
André Luis Fernandes LopesLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil.
Conceição da Silva MartinsNucleus of Studies in Microscopy and Image Processing (NEMPI), Federal University of Ceará, St. Delmiro de Farias, sn, Fortaleza, Ceará, CEP 60430-270, Brazil.
Letícia de Sousa ChavesLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil.
Lucas Antonio Duarte NicolauLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil.
Gilberto Santos CerqueiraNucleus of Studies in Microscopy and Image Processing (NEMPI), Federal University of Ceará, St. Delmiro de Farias, sn, Fortaleza, Ceará, CEP 60430-270, Brazil.
Jand Venes Rolim MedeirosLaboratory of Pharmacology of Inflammation and Gastrointestinal Disorders (LAFIDG), Parnaiba Delta Federal University (UFDPar), Av. São Sebastião, 2819, Parnaíba, PI, CEP 64202-020, Brazil. jandvenes@ufpi.edu.br.ORCID http://orcid.org/0000-0002-7234-3382
Universidade Federal do Ceará · BRBNP Paribas (France) · FR

Funding

Fundação de Amparo à Pesquisa do Estado do Piauí FAPEPI/MCTIC/CNPq N° 008/2018
6 · The paper itself

Abstract

Oral mucositis is an inflammation of the oral mucosa mainly resulting from the cytotoxic effect of 5-fluorouracil (5-FU). The literature shows anti-inflammatory action of L-cysteine (L-cys) involving hydrogen sulfide (H

Indexed as

AnimalsAnti-Inflammatory AgentsAntimetabolites, AntineoplasticAntioxidantsCricetinaeCyclooxygenase 2CysteineFluorouracilHydrogen SulfideInflammationMaleNitric Oxide Synthase Type IIStomatitisAnti-Inflammatory AgentsAntimetabolites, AntineoplasticAntioxidantsCyclooxygenase 2CysteineFluorouracilHydrogen SulfideNitric Oxide Synthase Type IIChemotherapyCytotoxicityHydrogen sulfideInflammationL-cysteineMucositis

Identifiers

PMID34410507
OpenAlexW3193284311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.