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ArticleInternational archives of occupational and environmental health2021

Occupational exposure to antineoplastic drugs: what about hospital sanitation personnel?

France Labrèche, Capucine Ouellet, Brigitte Roberge, Nicolas J Caron, Ahmed Yennek, Jean-François Bussières

Abstract read
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In one paragraph

Article in International archives of occupational and environmental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

France LabrècheChemical, Biological, Mechanical and Physical Risk Prevention, Institut de recherche Robert-Sauvé en santé et en sécurité du travail, 505 De Maisonneuve Blvd. West, Montréal, QC, H3A 3C2, Canada. france.labreche@irsst.qc.ca.ORCID http://orcid.org/0000-0001-8722-0433
Capucine OuelletChemical, Biological, Mechanical and Physical Risk Prevention, Institut de recherche Robert-Sauvé en santé et en sécurité du travail, 505 De Maisonneuve Blvd. West, Montréal, QC, H3A 3C2, Canada.
Brigitte RobergeChemical, Biological, Mechanical and Physical Risk Prevention, Institut de recherche Robert-Sauvé en santé et en sécurité du travail, 505 De Maisonneuve Blvd. West, Montréal, QC, H3A 3C2, Canada.
Nicolas J CaronCentre de Toxicologie du Québec, Institut national de santé publique du Québec, Québec, QC, Canada.
Ahmed YennekService de santé au travail, Direction de santé publique de 1 Estrie, CIUSSE - CHUS de Sherbrooke, Sherbrooke, QC, Canada.
Jean-François BussièresDépartement de pharmacie, Unité de recherche en pratique pharmaceutique, CHU Sainte-Justine, Montreal, QC, Canada.

Funding

Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail 2014-0001
6 · The paper itself

Abstract

objectiveOccupational exposure to antineoplastic drugs (ANPs) occurs mainly through dermal contact. Our study was set up to assess the potential exposure of hospital sanitation (HS) personnel, for whom almost no data are available, through contamination of surfaces they regularly touch.

methodsIn the oncology departments of two hospitals around Montreal, surface wipe samples of 120-2000 cm

resultsOverall, 60.9% of 212 surface samples presented at least one ANP above the limits of detection (LOD). Cyclophosphamide and gemcitabine were most often detected (52% and 31% of samples respectively), followed by 5-fluorouracil and irinotecan (15% each). Highest concentrations of five ANPs were found in outpatient clinics on toilet floors (5-fluorouracil, 49 ng/cm

conclusionsA notable proportion of surfaces showed measurable levels of ANPs, with highest concentrations found on surfaces cleaned by HS personnel, who would benefit from appropriate preventive training. As potential sources of worker exposure, several hospital surfaces need to be regularly monitored to evaluate environmental contamination and efficacy of cleaning.

Indexed as

Personnel, HospitalAdultAntineoplastic AgentsCyclophosphamideCytarabineDeoxycytidineDocetaxelFemaleFluorouracilGemcitabineHandHospitalsHumansIfosfamideIrinotecanMaleAntineoplastic AgentsCyclophosphamideCytarabineDeoxycytidineDocetaxelFluorouracilGemcitabineIfosfamideIrinotecanMethotrexatePaclitaxelVinorelbineAntineoplastic agentsHospital housekeepingOccupational exposureOncology

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.