Evidence map›Paper›PMID 34410452›Full record

ArticlePediatric radiology2021

Ferumoxytol magnetic resonance imaging detects joint and pleural infiltration of bone sarcomas in pediatric and young adult patients.

Ashok J Theruvath, Ali Rashidi, Ramya R Nyalakonda, Raffi S Avedian, Robert J Steffner, Sheri L Spunt, Heike E Daldrup-Link

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ashok J TheruvathDepartment of Radiology, Pediatric Molecular Imaging Program, Stanford University, 725 Welch Road, Stanford, CA, 94304, USA.
Ali RashidiDepartment of Radiology, Pediatric Molecular Imaging Program, Stanford University, 725 Welch Road, Stanford, CA, 94304, USA.
Ramya R NyalakondaDepartment of Radiology, Pediatric Molecular Imaging Program, Stanford University, 725 Welch Road, Stanford, CA, 94304, USA.
Raffi S AvedianDepartment of Orthopedic Surgery, Lucile Packard Children's Hospital, Stanford University, Stanford, CA, USA.
Robert J SteffnerDepartment of Orthopedic Surgery, Lucile Packard Children's Hospital, Stanford University, Stanford, CA, USA.
Sheri L SpuntDepartment of Pediatrics, Pediatric Hematology/Oncology, Lucile Packard Children's Hospital, Stanford, CA, USA.
Heike E Daldrup-LinkDepartment of Radiology, Pediatric Molecular Imaging Program, Stanford University, 725 Welch Road, Stanford, CA, 94304, USA. heiked@stanford.edu.ORCID 0000-0002-4929-819X
Lucile Packard Children's Hospital · USStanford University · US

Funding

Personalized Whole Body Staging for Children with Cancer: A Solution to the Conundrum of Long-Term Side Effects from CT and PET/CT ScansR01HD081123 · NICHD · STANFORD UNIVERSITY · PI DALDRUP-LINK, HEIKE ELIZABETH · 2015 to 2019
$2.5M
NICHD NIH HHS R01 HD081123
6 · The paper itself

Abstract

backgroundThe diagnosis of joint infiltration by a malignant bone tumor affects surgical management. The specificity of standard magnetic resonance imaging (MRI) for diagnosing joint infiltration is limited. During our MRI evaluations with ferumoxytol nanoparticles of pediatric and young adult patients with bone sarcomas, we observed a surprising marked T1 enhancement of joint and pleural effusions in some patients but not in others.

objectiveTo evaluate if nanoparticle extravasation differed between joints and pleura with and without tumor infiltration. MATERIALS AND

methodsWe retrospectively identified 15 pediatric and young adult patients (mean age: 16±4 years) with bone sarcomas who underwent 18 MRI scans at 1 h (n=7) or 24 h (n=11) after intravenous ferumoxytol infusion. Twelve patients also received a gadolinium-enhanced MRI. We determined tumor invasion into the joint or pleural space based on histology (n=11) and imaging findings (n=4). We compared the signal-to-noise ratios (SNR) and contrast-to-noise ratios (CNR) of the joint or pleural fluid for tumors with and without invasion using a Mann-Whitney U test.

resultsMRI scans 24 h after intravenous ferumoxytol infusion demonstrated a positive T1 enhancement of the effusion in all joints and pleural spaces with tumor infiltration and no joint or pleural space without infiltration. Corresponding SNR (P=0.004) and CNR (P=0.004) values were significantly higher for joints and pleural spaces with tumor infiltration than without. By contrast, unenhanced MRI, gadolinium-enhanced MRI and 1-h post-contrast ferumoxytol MRI did not show any enhancement of the joint or pleural effusion, with or without tumor infiltration.

conclusionThis pilot study suggests that 24-h post-contrast ferumoxytol MRI scans can noninvasively differentiate between joints with and without tumor infiltration.

Indexed as

Ferrosoferric OxideOsteosarcomaAdolescentAdultChildContrast MediaHumansMagnetic Resonance ImagingPilot ProjectsPleuraRetrospective StudiesYoung AdultContrast MediaFerrosoferric OxideCancerChildrenFerumoxytolIron oxide nanoparticlesJointMagnetic resonance imagingMolecular imagingPleural spaceSarcomaYoung adults

Identifiers

PMID34410452
PMCPMC8602726
OpenAlexW3195156910

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.