Evidence map›Paper›PMID 34410368›Full record

ReviewFEMS microbiology reviews2022

The ins and outs of Bacillus proteases: activities, functions and commercial significance.

Colin R Harwood, Yoshimi Kikuchi

Open access · bronzeAbstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 93 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Genome sequence of protease-freeMicrobiology resource announcements · 2026
    Article
  9. Genome sequence of protease-freeMicrobiology resource announcements · 2026
    Article
  10. Evolutionary bioenergetics of sporulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Biocontrol efficiency of nativeCurrent research in microbial sciences · 2026
    Article
  14. FEMS microbes · 2026
    Article
  15. The secreted proteasesVirulence · 2025
    Article
  16. The secreted proteasesVirulence · 2025
    Article
  17. Article
  18. Impact of expression systems on the transcriptome ofApplied and environmental microbiology · 2025
    Article
  19. Composting Poultry Feathers with KeratinolyticMaterials (Basel, Switzerland) · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Colin R HarwoodCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4AX, UK.ORCID 0000-0002-3624-0001
Yoshimi KikuchiResearch Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., Kawasaki 210-8681, Japan.
Ajinomoto (Japan) · JPNewcastle University · GB

Funding

Newcastle University
6 · The paper itself

Abstract

Because the majority of bacterial species divide by binary fission, and do not have distinguishable somatic and germline cells, they could be considered to be immortal. However, bacteria 'age' due to damage to vital cell components such as DNA and proteins. DNA damage can often be repaired using efficient DNA repair mechanisms. However, many proteins have a functional 'shelf life'; some are short lived, while others are relatively stable. Specific degradation processes are built into the life span of proteins whose activities are required to fulfil a specific function during a prescribed period of time (e.g. cell cycle, differentiation process, stress response). In addition, proteins that are irreparably damaged or that have come to the end of their functional life span need to be removed by quality control proteases. Other proteases are involved in performing a variety of specific functions that can be broadly divided into three categories: processing, regulation and feeding. This review presents a systematic account of the proteases of Bacillus subtilis and their activities. It reviews the proteases found in, or associated with, the cytoplasm, the cell membrane, the cell wall and the external milieu. Where known, the impacts of the deletion of particular proteases are discussed, particularly in relation to industrial applications.

Indexed as

BacillusPeptide HydrolasesBacillus subtilisBacterial ProteinsCell DivisionBacterial ProteinsPeptide Hydrolasesdegradationprotein foldingprotein processingprotein quality controlproteostasis

Identifiers

PMID34410368
PMCPMC8767453
OpenAlexW3194287150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.