Evidence map›Paper›PMID 34410326›Full record

ArticleThe Journal of experimental medicine2021

The microbial one-hit wonder.

Brigida A Rusconi, Rodney D Newberry

Abstract readComment
In one paragraph

Article in The Journal of experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Brigida A RusconiDepartment of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO.
Rodney D NewberryDepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO.ORCID 0000-0002-4152-5191

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
GOBLET CELLS IN INTESTINAL IMMUNE HOMEOSTATSISR01DK097317 · NIDDK · WASHINGTON UNIVERSITY · PI NEWBERRY, RODNEY D · 2012 to 2025
$5.6M
The Role of Route of Entry by Bacterial Antigens on Colonic T Cell ResponsesR01AI136515 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S, NEWBERRY, RODNEY D · 2018 to 2022
$2.8M
GUT SPECIFIC AND TIME-LIMITED EVENTS IN EARLY LIFE PROMOTING TOLERANCEU01AI131342 · NIAID · WASHINGTON UNIVERSITY · PI NEWBERRY, RODNEY D, TARR, PHILLIP I · 2017 to 2021
$2.2M
S1P as regulator of neonatal mucosal immune development and injuryK01DK125606 · NIDDK · WASHINGTON UNIVERSITY · PI RUSCONI, BRIGIDA AGNESE · 2020 to 2024
$679k
NIAID NIH HHS R01 AI136515NIAID NIH HHS U01 AI131342NIDDK NIH HHS K01 DK125606NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK097317NIH HHS DK097317
6 · The paper itself

Abstract

Intestinal inflammation, in the absence of infection, occurs from contributions by genetics and environment. Chen et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210324) challenge this concept by demonstrating that a dominant transmissible dysbiotic microbial community predisposes to intestinal inflammation in absence of genetic alterations.

Indexed as

InflammationHumans

Identifiers

PMID34410326
PMCPMC8383817

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.