Evidence map›Paper›PMID 34410223›Full record

ArticleParasite (Paris, France)2021

Does the in vitro egg hatch test predict the failure of benzimidazole treatment in Haemonchus contortus?

Michal Babják, Alžbeta Königová, Michaela Urda Dolinská, Tomas Kupčinskas, Jaroslav Vadlejch, Georg von Samson-Himmelstjerna, Saulius Petkevičius, Marián Várady

Open access · goldAbstract read
In one paragraph

Article in Parasite (Paris, France), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Michal BabjákInstitute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia.
Alžbeta KönigováInstitute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia.
Michaela Urda DolinskáInstitute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia.
Tomas KupčinskasLithuanian University of Health Sciences, Tilzes 18, 47181 Kaunas, Lithuania.
Jaroslav VadlejchDepartment of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Prague Suchdol, Czech Republic.
Georg von Samson-HimmelstjernaFreie Universität Berlin, Institute for Parasitology and Tropical Veterinary Medicine, Robert von Ostertag Str. 7-13, 14163 Berlin, Germany.
Saulius PetkevičiusLithuanian University of Health Sciences, Tilzes 18, 47181 Kaunas, Lithuania.
Marián VáradyInstitute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia.
Institute of Parasitology of the Slovak Academy of Sciences · SKLithuanian University of Health Sciences · LTSlovak Academy of Sciences · SKCzech University of Life Sciences Prague · CZFreie Universität Berlin · DE

Funding

agentúra ministerstva školstva, vedy, výskumu a športu sr VEGA 2/0099/19agentúra na podporu výskumu a vývoja APVV-18-0131european cooperation in science and technology COMBAR CA16230
6 · The paper itself

Abstract

Considerable research has been directed towards optimising in vitro tests that can diagnose resistance in pre-parasitic stages of parasites. The objective of this study was to compare the in vivo faecal egg count reduction test (FECRT), the in vitro egg hatch test (EHT), and the molecular determination of the frequency of a codon 200 allele of β-tubulin isotype 1 associated with benzimidazole resistance in larval stages of Haemonchus contortus obtained from infected goats. Animals were infected with composite infective doses representing 10, 20, 30, 40, 60, and 80% resistant alleles. Faecal samples for the EHT were collected on 28, 33, and 35 days post-infection. The results of the in vivo FECRT indicated that albendazole treatment reduced infections consisting of composite doses of 10, 20, 30, 40, 60, and 80% larvae of the resistant isolate by 91.3, 78.0, 63.3, 48.4, 36.5, and 41.4%, respectively. The drug concentration at which 50% of the eggs were prevented from developing hatching larvae (ED

Indexed as

AnthelminticsHaemonchusSheep DiseasesAnimalsBenzimidazolesDrug ResistanceFecesIn Vitro TechniquesParasite Egg CountSheepAnthelminticsBenzimidazolesAnthelmintic resistanceDetection methodsEgg hatch testGoatsHaemonchus contortus

Identifiers

PMID34410223
PMCPMC8375488
OpenAlexW3193394751

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.