ArticleThe journal of nutrition, health & aging2021
Longitudinal Association between Late-Life Depression (LLD) and Frailty: Findings from a Prospective Cohort Study (MiMiCS-FRAIL).
Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The Frail Depressed Patient: A Narrative Review on Treatment Challenges.Clinical interventions in aging · 2022Pooled it
- Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Associations between frailty, biomarkers of cerebral pathology, cognitive and neuropsychiatric symptoms: a memory clinic study.The Journal of frailty & aging · 2026Article
- An interpretable machine learning model predicts frailty risk in middle-aged and older adults with gastrointestinal disease: a longitudinal study.Scientific reports · 2026Article
- The association of depressive symptoms and dietary inflammatory index with frailty in older adults with diabetes.BMC psychiatry · 2026Article
- Late-Onset Depression in an Aging World: A Multidimensional Perspective on Risks, Mechanisms, and Treatment.Geriatrics (Basel, Switzerland) · 2026Review
- Cellular heterogeneity and multicellular mechanisms in the pathogenesis of late-life depression: insights from single-cell and spatial multi-omics.Frontiers in immunology · 2026Review
- Grip strength in the association between frailty and new-onset depression in older adults: a multinational longitudinal study.Frontiers in public health · 2026Article
- Predictors of fatigue in Individuals With Late-Life Depression.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- The relationship between frailty and depression in Chinese elderly prostate cancer patients following radical surgery: the mediating effect of sleep disturbances.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Predictive features analysis and nomogram construction for predicting depression in elderly patients.Frontiers in psychology · 2025Article
- Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study.BMC psychiatry · 2024Article
- Changes in frailty and depressive symptoms among middle-aged and older Chinese people: a nationwide cohort study.BMC public health · 2024Article
- Effects of Social Support Provided by Disabled Older Adults to Others on Their Own Depressive Symptoms: A Moderated Mediation Model.Psychology research and behavior management · 2024Article
- Association of depression and sleep quality with frailty: a cross-sectional study in China.Frontiers in public health · 2024Article
- Causal relationship between depression and aging: a bidirectional two-sample Mendelian randomization study.Aging clinical and experimental research · 2023Article
- Effectiveness of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression in the Elderly: A Retrospective Natural Analysis.Journal of clinical medicine · 2023Article
- Loneliness and Frailty Among Middle-Aged and Aging Sexual Minority Men Living With or Without HIV: A Longitudinal Cross-Lagged Panel Analysis.Innovation in aging · 2023Article
- Association of frailty with cognitive impairment and functional disability in older adults with affective disorders: a brief research report.Frontiers in psychiatry · 2023Article
- Prevalence of Frailty and Its Association with Depressive Symptoms among European Older Adults from 17 Countries: A 5-Year Longitudinal Study.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of the present study was to investigate whether late-life depression (LLD) is associated with incident frailty over time.
designProspective cohort study, one-year follow-up.
settingGeriatric outpatient clinic, Southwestern of Brazil.
participants181 follow-up participants aged 60 years or over. MEASUREMENTS: Depressive disorders were classified as Major Depressive disorder (MDD) or Subthreshold Depression (STD) according to DSM-5 criteria. Depressive symptoms were assessed with validated versions of 15-item Geriatric Depression Scale (GDS-15) and 9-item Patient Health Questionnaire (PHQ-9). We performed binary logistic regressions to estimate the odds ratio (OR) for frailty in LLD adjusting for multiple confounders. Participants who were frail at baseline were excluded from the analyses according to measures of frailty (FRAIL questionnaire and 36-item Frailty Index, FI-36). We also estimated the risk ratio or relative risk (RR) and the risk difference (RD) for incident frailty.
resultsWe observed a 2 to 4-fold increased risk for incident frailty among participants with LLD. The presence of a depressive disorder was significantly associated with the onset of frailty (adjusted OR for FRAIL and FI-36: 3.07 [95% CI = 1.03 - 9.17] and 3.76 [95% CI = 1.09 - 12.97], respectively. Notably, the risk for frailty due to LLD was significantly higher with the FI-36 compared to the FRAIL (RR: 3.03 versus 2.23). RD was of 17.3% and 12.7% with the FRAIL and the FI-36, respectively.
conclusionOur data support the association between LLD and incident frailty over one year among geriatric outpatients, reinforcing longitudinal evidence from population-based studies.
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